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圈养北树鼩的寿命与生殖衰老:性别差异与双亲年龄对繁殖输出的轻微影响

Lifespan and reproductive aging in captive Northern tree shrews (Tupaia belangeri)

PubMed · 生殖内分泌/遗传/保存 · Geroscience (IF 未收录) · 文献 · 2026-10-31
Bynum JC, Biga PR, Grytz R, IISAGE Consortium, Riddle NC
DOI 10.1007/s11357-026-02623-y · PMID 42963494 · 原文链接 ↗ · Scholar
综合 48.0 模型 48.0 · deepseek/deepseek-flash · 强度 low 未入选(阈值 60.0) 生殖衰老
新颖 45严谨 55影响 35领域相关 45转化 25

摘要

树鼩是与灵长类亲缘较近的小型哺乳动物,在视觉系统等形态生理特征上比啮齿类更接近人类,是潜在的临床前模型,但其基础种群统计数据长期缺乏。作者利用美国阿拉巴马大学伯明翰分校北树鼩(Tupaia belangeri)繁殖群体的现存记录,分析年龄对个体繁殖成功率的影响及寿命的性别差异。结果显示:雄性中位寿命长于雌性,但90%最大寿命与死亡率无性别差异;总体上几乎未见明显生殖衰老迹象,仅双亲年龄均偏大时繁殖输出略有下降。该研究为树鼩作为衰老与生殖研究模型时的年龄分组选择提供了基础数据,但为单中心回顾性记录分析,样本量与统计细节在摘要中未充分呈现。

原文摘要

Tree shrews are small mammals closely related to primates, which originate in Southeast Asia. In several aspects of their morphology and physiology, tree shrews more closely resemble humans than rodents. For example, the development of their visual system parallels that of humans, making them a desirable model species for pre-clinical research. Despite the use of tree shrews in research for over 50 years, little is known about the basic demography of tree shrews. No detailed lifespan studies are available for tree shrews, and it is unclear if females and males experience aging similarly. This information is needed given the increased use of tree shrews in research to ensure the proper selection of age groups. Here, we utilize the existing records of the T. belangeri (Northern tree shrew) colony at the University of Alabama at Birmingham to investigate how age impacts the reproductive success of individuals and examine sex differences in lifespan. We find that at the UAB breeding colony, T. belangeri males have an increased median lifespan compared to females, but detect no differences in maximum lifespan (90% survival) and mortality. Furthermore, there is little evidence of reproductive aging in general, but having two older parents slightly decreases reproductive output.

推荐理由:首次系统描述北树鼩群体的寿命性别差异与繁殖衰老模式,对使用该动物模型的研究者在年龄分组设计上有参考价值;但属单中心回顾性描述性数据,与人类ART或胚胎研究的直接关联有限,非生殖医学读者可略过。

关键词:树鼩 · 生殖衰老 · 寿命 · 动物模型 · 繁殖输出 · 性别差异

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条目 #335 · 入库 2026-11-08 11:44 · JSON · Journal Article