表观遗传学与子宫内膜异位症的研究进展与趋势：一项文献计量学分析
Research progress and trends on epigenetics and endometriosis: a bibliometric analysis
摘要
该研究以R包bibliometrix、VOSviewer与CiteSpace为工具，对2005—2026年Web of Science（据文中描述）收录的1175篇子宫内膜异位症表观遗传学文献进行文献计量与可视化分析。结果显示，中国发文量居首（442篇），复旦大学为最高产机构（76篇，6.4%），Taylor Hugh S.为最高产作者（33篇）。研究热点集中于DNA甲基化（HOXA10、SF-1、PR-B、ERβ、GATA因子）、组蛋白修饰与非编码RNA调控；近期趋势转向新型表观遗传生物标志物与靶向治疗。作者认为DNA甲基化与非编码RNA是该领域核心，未来应聚焦标志物发现与临床转化。原文仅提供摘要，未报告具体检索数据库与质量评价细节。
原文摘要
BACKGROUND: Endometriosis, a common gynecological disorder characterized by ectopic endometrial tissue, has complex epigenetic mechanisms. This study provides a comprehensive bibliometric analysis of research trends in endometriosis epigenetics. METHODS: Articles on endometriosis epigenetics published from 2005 to 2026 were analyzed using the R package "bibliometrix," VOSviewer, and CiteSpace to visualize research hotspots, key contributors, and emerging topics. RESULTS: A total of 1175 articles were included, with the China leading (442 publications). Fudan University is the top institutions (76 articles, 6.4%), and Professor Taylor Hugh S. was the most prolific author (33 articles, 2.8%). Research hotspots included DNA methylation (notably HOXA10, SF-1, PR-B, ERβ, and GATA factors), histone modifications, and non-coding RNA regulation. Recent trends focus on novel epigenetic biomarkers and targeted therapies. CONCLUSIONS: This analysis highlights DNA methylation and non-coding RNAs as central in endometriosis epigenetics. Continued research should prioritize discovering biomarkers and translations into clinical practice.
推荐理由：属规范的文献计量学综述，可快速了解子宫内膜异位症表观遗传研究的热点分布、核心团队与趋势走向，适合作为选题与合作的参考；但不产生新机制或新数据，对ART实验室与临床决策的直接推动有限。
文献解读
尚未生成。