{"id":251,"title":"Research progress and trends on epigenetics and endometriosis: a bibliometric analysis","title_zh":"表观遗传学与子宫内膜异位症的研究进展与趋势：一项文献计量学分析","url":"https://pubmed.ncbi.nlm.nih.gov/42978001","doi":"10.1186/s13148-026-02220-y","pmid":"42978001","journal":"Clin Epigenetics","kind":"paper","lang":"en","published_at":"2026-08-03T00:00:00+00:00","fetched_at":"2026-11-08T03:44:00+00:00","authors":["Li X","Bai Y","Luo S","Jin Y","Yang J","An X","Liu D"],"primary_topic":"endometrium","topics":[{"slug":"endometrium","score":5.0,"hits":["endometrial","endometriosis"]},{"slug":"repro-genetics","score":1.0,"hits":["dna methylation"]},{"slug":"ethics-policy","score":1.0,"hits":["regulation"]}],"topic_score":5.0,"preference_score":0.0,"preference_labels":[],"llm_score":58.0,"final_score":58.0,"score_dims":{"novelty":35,"rigor":62,"impact":52,"relevance":62,"translation":45},"recommend_reason":"属规范的文献计量学综述，可快速了解子宫内膜异位症表观遗传研究的热点分布、核心团队与趋势走向，适合作为选题与合作的参考；但不产生新机制或新数据，对ART实验室与临床决策的直接推动有限。","keywords":["文献计量学","子宫内膜异位症","DNA甲基化","非编码RNA","组蛋白修饰","表观遗传标志物"],"selected":0,"story_id":475,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-uterus-pregnancy","source_name":"PubMed · 内膜/植入/早孕","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":null,"journal_tier":"unknown","journal_if":null,"is_mock":false,"summary_zh":"该研究以R包bibliometrix、VOSviewer与CiteSpace为工具，对2005—2026年Web of Science（据文中描述）收录的1175篇子宫内膜异位症表观遗传学文献进行文献计量与可视化分析。结果显示，中国发文量居首（442篇），复旦大学为最高产机构（76篇，6.4%），Taylor Hugh S.为最高产作者（33篇）。研究热点集中于DNA甲基化（HOXA10、SF-1、PR-B、ERβ、GATA因子）、组蛋白修饰与非编码RNA调控；近期趋势转向新型表观遗传生物标志物与靶向治疗。作者认为DNA甲基化与非编码RNA是该领域核心，未来应聚焦标志物发现与临床转化。原文仅提供摘要，未报告具体检索数据库与质量评价细节。","summary":"BACKGROUND: Endometriosis, a common gynecological disorder characterized by ectopic endometrial tissue, has complex epigenetic mechanisms. This study provides a comprehensive bibliometric analysis of research trends in endometriosis epigenetics. METHODS: Articles on endometriosis epigenetics published from 2005 to 2026 were analyzed using the R package \"bibliometrix,\" VOSviewer, and CiteSpace to visualize research hotspots, key contributors, and emerging topics. RESULTS: A total of 1175 articles were included, with the China leading (442 publications). Fudan University is the top institutions (76 articles, 6.4%), and Professor Taylor Hugh S. was the most prolific author (33 articles, 2.8%). Research hotspots included DNA methylation (notably HOXA10, SF-1, PR-B, ERβ, and GATA factors), histone modifications, and non-coding RNA regulation. Recent trends focus on novel epigenetic biomarkers and targeted therapies. CONCLUSIONS: This analysis highlights DNA methylation and non-coding RNAs as central in endometriosis epigenetics. Continued research should prioritize discovering biomarkers and translations into clinical practice.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}