植入前遗传学检测(PGT):患者与提供者偏好、伦理考量及产科与新生儿危害分析
Preimplantation Genetic Testing: Patient and Provider Preferences, Ethical Considerations, and Obstetrical and Neonatal Harms Analyses
摘要
加拿大Ontario Health对PGT-A、PGT-M和PGT-SR系列卫生技术评估的共性发现进行总结,方法包括定性文献快速综述、患者直接参与、PGT伦理文献综述,以及滋养层活检相关产科和新生儿危害的快速综述;PGT各技术的临床与经济影响另文发表。报告聚焦患者与提供者偏好、伦理框架及活检安全性,但摘要未给出具体效应量。
原文摘要
Preimplantation genetic testing (PGT) refers to a group of genetic tests that analyze the DNA of embryos for chromosomal or genetic anomalies prior to the transfer to the uterus during in vitro fertilization (IVF). Ontario Health conducted a series of health technology assessments (HTA) of PGT, including assessment of PGT-A, PGT-M, and PGT-SR. In this report, we summarize the findings common to all 3 HTAS, including a rapid review of the qualitative literature, direct patient engagement, and a review of published literature examining ethical considerations relating to PGT. We also undertook a rapid review of the obstetrical and neonatal harms of PGT using trophectoderm biopsy. Reviews of the clinical and economic impact of PGT-A, the clinical impact of PGT-M, and the clinical impact of PGT-SR have been published separately.
推荐理由:该卫生技术评估系统整合PGT的患者偏好、伦理考量与滋养层活检的产科/新生儿安全性证据,对PGT临床咨询、政策制定和实验室风险沟通有参考价值;但属证据综合而非原创机制研究。
文献解读
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所属事件:植入前遗传学检测(PGT):患者与提供者偏好、伦理考量及产科与新生儿危害分析 热度 0.0 · 0 个来源
收录来源(2)
- 11-08 11:43PubMed · 辅助生殖临床
- 11-08 11:44PubMed · 生殖内分泌/遗传/保存