乳腺癌肿瘤学特征对卵巢储备及首次控制性促排卵结局的影响
Impact of Oncological Characteristics on Ovarian Reserve and Outcomes of the First Controlled Ovarian Stimulation Cycle in Patients with Breast Cancer
摘要
该单中心回顾性队列研究纳入2020年1月至2026年6月于郑州大学第三附属医院生殖医学中心接受生育力保存的67例乳腺癌患者，按组织学分级、肿瘤分期、ER状态、三阴性状态及Ki-67表达分组，评估上述肿瘤学特征对基线卵巢储备与首次控制性促排卵（COS）结局的影响。摘要可见信息显示，各分组间卵巢储备与COS结局差异均无统计学意义（P>0.05）；获成熟卵母细胞≥8枚者的AMH及双侧窦卵泡数显著更高。原文摘要不完整，其余结局指标与多因素分析结论无法确认。
原文摘要
Abstract Objective To evaluate the effects of histological grade, tumor stage, estrogen receptor (ER) status, triple-negative breast cancer (TNBC) status, and Ki-67 expression level on baseline ovarian reserve and the outcomes of the first controlled ovarian stimulation (COS) cycle in breast cancer patients undergoing fertility preservation, and to identify factors associated with an optimal COS outcome. Methods This single-center retrospective cohort study analyzed the clinical data of 67 patients with breast cancer who underwent fertility preservation at the Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University between January 2020 and June 2026. Patients were grouped according to histological grade (grade I vs. grades II–III), tumor stage (stage I vs. stages II–III), ER status (ER-positive vs. ER-negative), TNBC status (TNBC vs. non-TNBC), and Ki-67 expression ( 0.05). AMH and bilateral AFC were significantly higher in patients with ≥ 8 mature oocytes than in those with
推荐理由：选题贴近生育力保存临床决策，提示肿瘤分子分型可能不构成COS结局的独立限制因素，对乳腺癌患者促排前的咨询有一定参考价值；但样本仅67例、单中心回顾性设计、摘要截断，结论强度有限，宜作浏览与线索参考。
文献解读
尚未生成。