Circular RNAs (circRNAs) are abundant and developmentally regulated in gonads, gametes, and preimplantation embryos, whereas NLRP3 inflammasome signaling has context-dependent roles in ovarian aging, spermatogenic stress, endometrial receptivity, implantation, and placental disease. Whether these two evidence streams constitute a functional regulatory axis in mammalian gametogenesis or early embryogenesis remains uncertain. In this regard, this review article aimed to identify direct reproductive mechanisms; reproductive functions without a demonstrated circRNA-NLRP3 bridge, association, or bioinformatic prediction; and mechanistic extrapolations from non-reproductive systems. Direct reproductive evidence was limited to four placental/trophoblast or granulosa-cell examples: circ_0001438/miR-942/NLRP3 signaling in preeclampsia-associated trophoblast models; circ_0081343-RBM8A regulation of NLRP3-linked pyroptosis in fetal-growth-restriction models; circ_0070987-associated pyroptosis in a dihydrotestosterone-treated granulosa-cell line; and hsa_circ_0003218 overexpression, which reduced NLRP3-pathway readouts in high-glucose HTR-8/SVneo trophoblasts in a gestational-diabetes study. No direct functional study was identified in mammalian sperm, oocytes, zygotes, cleavage-stage embryos, blastocysts, or the male germ line. Accordingly, circRNA detection, co-expression, host-gene enrichment, and predicted competing endogenous RNA networks should be regarded as hypothesis-generating rather than as proof of NLRP3 regulation. CircRNAs in seminal plasma and maternal blood show candidate biomarker potential, but external validation remains limited, and no combined reproductive circRNA-NLRP3 panel has been validated. Similarly, circRNA mimics, antisense approaches, circRNA-encoded peptides, extracellular vesicle (EVs) delivery, and combined circRNA/NLRP3 therapy remain preclinical or hypothetical in terms of reproduction. The most immediate priorities are cell-type- and stage-resolved perturbation studies, binding and rescue experiments, quantitative inflammasome readouts, reproductive safety assessment, and prospective biomarker validation.