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将生物停滞扩展至妊娠:界定一个尚未被研究的生物医学问题

Extending biostasis to pregnancy: defining an unexamined biomedical problem

PubMed · 内膜/植入/早孕 · Front Reprod Health · 文献 · 2026-10-21
Radomski CA, Vita-More N
DOI 10.3389/frph.2026.1950341 · PMID 42985059 · 原文链接 ↗ · Scholar
综合 62.0 模型 62.0 · deepseek/deepseek-flash · 强度 low 已入选 卵母细胞与卵泡生物学 精子与男性生殖 胚胎学与实验室技术 子宫内膜与植入
新颖 82严谨 55影响 45领域相关 50转化 30

摘要

作者系统检索文献后指出,尽管胚胎、卵母细胞和精子冷冻已常规应用,且育龄人群会加入生物停滞组织,但尚无研究直接探讨妊娠个体的冷冻保存或宫内胚胎/胎儿的保存。文章综合低温生物学、生殖与发育生物学、临床医学、生物伦理与法律,提出将妊娠个体与孕体视为“一个身体、两个生物学系统”的概念框架,区分已有证据、可检验假说与推测情景,并提出两条可证伪假说:全身体灌注下冷冻保护剂跨母胎界面的递送受限,以及母胎浓度梯度随孕龄变化;同时分析四种保存情景、母体脑死亡后躯体支持先例及同意与管辖问题。文章不提出临床方案或可行性主张,而是给出研究议程与组织政策建议。

原文摘要

Our review of the scientific literature identified no studies directly addressing the cryopreservation of a pregnant individual or the preservation of an embryo or fetus in utero, despite the routine use of cryopreservation for embryos, oocytes, and sperm in reproductive medicine and the enrollment of individuals of reproductive age in biostasis organizations. This paper defines this unexamined problem by synthesizing evidence from cryobiology, reproductive and developmental biology, clinical medicine, bioethics, and law. It develops a conceptual framework that treats the pregnant individual and conceptus as one physical body containing two biologically distinct systems, and distinguishes established evidence, testable hypotheses, and speculative scenarios. Two falsifiable hypotheses follow: that cryoprotectant delivery across the maternal-fetal interface is rate-limited under whole-body perfusion, and that the resulting maternal-fetal concentration gradient varies with gestational age. The paper analyzes four preservation scenarios, the clinical precedent of somatic support after maternal brain death, and the consent, surrogate decision-making, and jurisdictional questions these scenarios raise. Membership data from three biostasis organizations indicate that roughly one in eight members of organizations reporting age data is a woman of reproductive age. The paper does not propose clinical protocols or claim feasibility. It sets out a prioritized research agenda and recommendations for organizational policy in a previously unexplored area of biomedical research.

推荐理由:概念新颖,首次系统界定妊娠个体与孕体冷冻保存这一空白问题,并给出可证伪假说与伦理政策议程;但无原始实验数据、无临床方案,对当前ART实验室和临床决策的直接转化价值有限,适合作为浏览与跨学科讨论素材。

关键词:生物停滞 · 妊娠冷冻保存 · 母胎界面 · 冷冻保护剂 · 研究议程 · 生物伦理

解读依据: 仅摘要 尚未抓取全文(未入选、分数未达阈值,或还没跑 fulltext 步骤)

文献解读

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所属事件:将生物停滞扩展至妊娠:界定一个尚未被研究的生物医学问题 热度 0.0 · 0 个来源

条目 #231 · 入库 2026-11-08 11:44 · JSON · Journal Article