{"id":83,"title":"The severity of preeclampsia in naturally conceived versus IVF-conceived pregnancies: a retrospective study","title_zh":"自然受孕与IVF受孕妊娠中子痫前期严重程度的比较：一项回顾性研究","url":"https://pubmed.ncbi.nlm.nih.gov/42979677","doi":"10.1080/10641955.2026.2753955","pmid":"42979677","journal":"Hypertens Pregnancy","kind":"paper","lang":"en","published_at":"2026-11-04T00:00:00+00:00","fetched_at":"2026-11-08T03:43:53+00:00","authors":["Chen Y","Jiang P","Li X","Hu L","Li J","Chen Q","Gu Y"],"primary_topic":"art-clinical","topics":[{"slug":"art-clinical","score":5.0,"hits":["in vitro fertilization","ivf"]},{"slug":"early-pregnancy","score":5.0,"hits":["preeclampsia","preterm birth"]},{"slug":"endometrium","score":1.0,"hits":["placental"]},{"slug":"repro-tox","score":1.0,"hits":["bmi"]},{"slug":"repro-aging","score":1.0,"hits":["maternal age"]}],"topic_score":5.0,"preference_score":5.0,"preference_labels":["可转化到 ART 实验室的发现"],"llm_score":62.0,"final_score":67.0,"score_dims":{"novelty":55,"rigor":55,"impact":58,"relevance":88,"translation":50},"recommend_reason":"针对“IVF是否加重子痫前期严重程度”这一存在争议的临床问题提供阴性结果，结论清晰；但属单中心回顾性设计，IVF组仅97例，对严重程度亚组比较的检验效能有限，新颖性与方法学强度一般，适合浏览。","keywords":["子痫前期","IVF","自然受孕","早发型子痫前期","围产结局"],"selected":1,"story_id":100,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-art","source_name":"PubMed · 辅助生殖临床","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":null,"journal_tier":"unknown","journal_if":null,"is_mock":false,"summary_zh":"该回顾性研究纳入498例子痫前期病例，其中自然受孕401例、IVF受孕97例，比较两种受孕方式下子痫前期的严重程度。结果显示，IVF组平均分娩孕周为36周，显著早于自然受孕组的37周（p=0.0002）；但早发型子痫前期比例（28% vs 19%，p=0.0732）与重度子痫前期比例（16% vs 23%，p=0.1667）均无统计学差异。校正母亲年龄、BMI、产次及双胎妊娠后，子痫前期发病孕周与早产率在两组间亦无差异。作者据此认为，IVF受孕虽增加子痫前期发生风险，但在该病发生后，其严重程度并未因受孕方式不同而加重。","summary":"Pregnancies conceived using in vitro fertilization (IVF) significantly increase the risk of developing preeclampsia. One possible explanation is that embryos grown outside the body may implant differently compared to natural conceptions, potentially affecting placental development and increasing the risk of preeclampsia. Clinically, preeclampsia is classified into early-onset and late-onset forms, as well as severe and mild forms. Although some studies suggested that preeclampsia severity may be more pronounced in IVF-conceived pregnancies, the findings were controversial. In this retrospective study, we compared the severity of preeclampsia between naturally conceived and IVF-conceived pregnancies. A total of 498 preeclampsia cases were included, with 401 cases occurring in naturally conceived pregnancies and 97 in IVF-conceived pregnancies. The mean gestational age at delivery in the IVF-conceived group was 36 weeks, significantly earlier than that in the naturally conceived group (37 weeks, p = 0.0002). Additionally, 27 (28%) women in the IVF-conceived group developed early-onset preeclampsia, which was no statistical difference from the naturally conceived group (78, 19%, p = 0.0732). There was no significant difference in the proportion of severe preeclampsia between the two groups (16% vs. 23%, p = 0.1667). Additionally, gestational age at the onset of preeclampsia and the incidence of preterm birth were not different between the two groups after adjusting for important confounders, including maternal age, BMI, parity, and twin pregnancy. In conclusion, there is a known link between IVF conception and the increased risk of developing preeclampsia. Our study found that the severity of preeclampsia, once it occurred, did not differ between the two modes of conception.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}