{"id":61,"title":"Institutional Perspectives on Assisted Reproductive Technology Using Third-Party Gametes in Japan: A Nationwide Survey of Assisted Reproductive Technology Facilities","title_zh":"日本第三方配子辅助生殖技术的机构立场：全国性ART设施调查","url":"https://pubmed.ncbi.nlm.nih.gov/42985477","doi":"10.1002/rmb2.70108","pmid":"42985477","journal":"Reprod Med Biol","kind":"paper","lang":"en","published_at":"2026-11-03T00:00:00+00:00","fetched_at":"2026-11-08T03:43:52+00:00","authors":["Takahashi N","Harada M","Koike H","Kawahara Y","Kitabatake Y","Kinutani M","Koizumi T","Suganuma M","Sugino N","Suzuki N","Tsujimura A","Hamatani T","Mizunuma N","Wada S","Hirota Y","Osuga Y"],"primary_topic":"art-clinical","topics":[{"slug":"art-clinical","score":7.0,"hits":["assisted reproductive","in vitro fertilization","intrauterine insemination","oocyte donation"]},{"slug":"male","score":2.0,"hits":["sperm","testicular"]},{"slug":"oocyte","score":1.0,"hits":["oocyte"]},{"slug":"ethics-policy","score":1.0,"hits":["legal"]}],"topic_score":7.0,"preference_score":0.0,"preference_labels":[],"llm_score":72.0,"final_score":72.0,"score_dims":{"novelty":55,"rigor":72,"impact":68,"relevance":82,"translation":70},"recommend_reason":"这是覆盖日本全国ART机构的大样本调查，系统呈现第三方配子ART的准入年龄、国籍与婚姻要求、适应证与心理社会支持等机构立场，对理解监管与伦理落地差异、开展跨境配子捐赠与政策比较有参考价值；但属于描述性研究，缺乏结局数据与机制创新。","keywords":["第三方配子","卵子捐赠","精子捐赠","机构调查","伦理与政策","辅助生殖技术"],"selected":1,"story_id":167,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-art","source_name":"PubMed · 辅助生殖临床","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":null,"journal_tier":"unknown","journal_if":null,"is_mock":false,"summary_zh":"本研究调查日本妇产科学会注册的634家辅助生殖机构，回收416份问卷并做描述性分析，旨在厘清各机构对使用第三方配子的ART的观点。结果显示，多数机构（94.6%）要求受者夫妇具备心理社会与经济稳定性；36.8%与54.3%的机构分别将日本国籍与合法婚姻作为受者条件。女性受者年龄下限为20–25岁、上限为43–45岁；卵子捐赠者上限多为35岁（67.9%），精子捐赠者上限较分散，以40岁最常见。供卵最常见适应证为高促性腺激素性性腺功能减退（87.5%），供精则为显微取精未获精子（97.3%）。结论：各机构在核心原则上高度一致，但具体准入与操作标准存在差异。","summary":"OBJECTIVE: To clarify institutional perspectives on assisted reproductive technology (ART) using third-party gametes. METHODS: We surveyed 634 facilities registered with the Japan Society of Obstetrics and Gynecology, and 416 responses were included in a descriptive analysis. RESULTS: Psychosocial and economic stability of ART recipient couples were considered necessary in most facilities (94.6%). Japanese nationality and legal marriage were necessary recipient criteria in 36.8% and 54.3% facilities, respectively. Lower and upper age limits for female recipients were 20-25 and 43-45 years, respectively, whereas most male partners had no upper age limit (34.6%-36.6%). The most common upper age limit for oocyte donors was 35 years (67.9%). In contrast, upper age limits for sperm donors were more dispersed, with 40 years being the most common age at response to intrauterine insemination (35.6%) and in vitro fertilization (35.9%). The most accepted indications were hypergonadotropic hypogonadism for oocyte donation (87.5%) and failure to retrieve sperm via micro-testicular sperm extraction for donor sperm treatment (97.3%). Most facilities considered psychosocial support necessary. CONCLUSIONS: This study provides a comprehensive overview of institutional perspectives on third-party ART in Japan. Although facilities showed substantial agreement on core principles, their views on specific eligibility and operational criteria varied.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}