{"id":520,"title":"eHLAstic reveals an extended canonical and non-canonical HLA-E immunopeptidome in human cancers","title_zh":"eHLAstic 揭示人类肿瘤中扩展的经典与非经典 HLA-E 免疫肽组","url":"https://doi.org/10.1016/j.celrep.2026.118216","doi":"10.1016/j.celrep.2026.118216","pmid":null,"journal":"Cell Reports","kind":"paper","lang":"en","published_at":"2026-11-01T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Hanqing Liao","Max N. Quastel","Chloe M. Shepherd","Annalisa Nicastri","Leron W. Kok","Andy van Hateren","Sam Palmer","Qian Yang","Aleksandra Dzhoneva","Bas Peeters","Estelle Marrer-Berger","Sebastiaan van Heesch","Geraldine M. Gillespie","Nicola Ternette"],"primary_topic":"repro-immunology","topics":[{"slug":"repro-immunology","score":3.0,"hits":["hla"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":46.0,"final_score":54.0,"score_dims":{"novelty":70,"rigor":60,"impact":20,"relevance":22,"translation":25},"recommend_reason":"这是肿瘤免疫肽组学的方法学进展，对 HLA-E 呈递图谱有扩展价值；但与生殖医学、辅助生殖及胚胎研究几乎无直接交叉，对 ART 实验室与临床决策的可用性很低，仅建议关注 HLA-E/子宫 NK 细胞免疫耐受方向的研究者作为背景参考。","keywords":["HLA-E","免疫肽组学","非经典 HLA-I","肿瘤免疫","质谱","抗原呈递"],"selected":0,"story_id":215,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"cell-rep","journal_tier":"cns-sub","journal_if":7.5,"is_mock":false,"summary_zh":"该研究（Cell Reports，2026）开发了 eHLAstic 分析流程，用于从质谱免疫肽组数据中系统鉴定 HLA-E 结合肽。作者在多种人类肿瘤中刻画了 HLA-E 免疫肽组，报道了除经典 HLA-E 信号肽之外更广泛的一批经典与非经典配体，提示 HLA-E 呈递谱比既往认识更为多样。原文摘要未提供，样本量、验证实验与统计细节无法从可见信息判断；该工作核心为肿瘤免疫学与免疫肽组学方法学，与生殖免疫仅有间接关联。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}