{"id":519,"title":"A genome-wide CRISPR screening identifies targets that drive tolerogenic dendritic cells","title_zh":"全基因组CRISPR筛选鉴定驱动耐受性树突状细胞的关键靶点","url":"https://doi.org/10.1016/j.celrep.2026.118212","doi":"10.1016/j.celrep.2026.118212","pmid":null,"journal":"Cell Reports","kind":"paper","lang":"en","published_at":"2026-11-01T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Xiaoguang Li","Tiankai Han","Liang Chen","Megha Suresh","Fedik Rahimov","Chao Gao","Jing Wang","Renze Ma","Joshua D. Stender","Kanstantsin Katlinski"],"primary_topic":"ethics-policy","topics":[{"slug":"ethics-policy","score":3.0,"hits":["crispr"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":55.0,"final_score":63.0,"score_dims":{"novelty":65,"rigor":55,"impact":40,"relevance":25,"translation":30},"recommend_reason":"全基因组CRISPR筛选耐受性树突状细胞靶点，方法上有一定新意，可为生殖免疫耐受（母-胎界面、植入）研究提供候选基因线索；但内容属通用免疫学，非生殖核心范畴，且无摘要可核，暂列为可浏览。","keywords":["CRISPR筛选","耐受性树突状细胞","免疫耐受","基因功能筛选","生殖免疫"],"selected":1,"story_id":216,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"cell-rep","journal_tier":"cns-sub","journal_if":7.5,"is_mock":false,"summary_zh":"该研究发表于 Cell Reports，采用全基因组CRISPR筛选策略，在树突状细胞模型中系统鉴定调控耐受性树突状细胞（tolerogenic DC）分化与功能的关键基因靶点，并列出候选基因清单。由于条目未提供摘要与正文，样本来源（人源/小鼠）、筛选文库、验证实验（如 T 细胞共培养、体内模型）及统计方法均无法确认，故方法学细节与结论强度需查阅原文后判断。对生殖免疫学而言，可能为母-胎界面免疫耐受与植入微环境研究提供候选分子线索。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}