{"id":518,"title":"Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization","title_zh":"大规模并行功能鉴定揭示肠道菌群对调控性DNA元件的调节作用","url":"https://doi.org/10.1016/j.molcel.2026.10.031","doi":"10.1016/j.molcel.2026.10.031","pmid":null,"journal":"Molecular Cell","kind":"paper","lang":"en","published_at":"2026-11-01T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Chadmirah Zaratiana","Yiamunaa M","Yong-An Lee","Agnes Bee Leng Ong","Tiffany Z.Y. Liu","Suet Mei Crystal Low","Shi Min Samantha Chang","Shaun Tan","Dayang Nurul Asyiqin Mustafa","Adheet Ganesh","Xuling Chang","Xiu Qi Koh","Sen Hee Tay","Wei Jie Jonathan Lee","Jian-Min Yuan","Chiea Chuen Khor","Woon-Puay Koh","Rajkumar Dorajoo","Yang E. Li","Kazuyuki Kasahara","Torsten Wuestefeld","Poshen B. Chen"],"primary_topic":"ethics-policy","topics":[{"slug":"ethics-policy","score":3.0,"hits":["regulatory"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":52.0,"final_score":60.0,"score_dims":{"novelty":68,"rigor":60,"impact":35,"relevance":15,"translation":20},"recommend_reason":"方法学上属于大规模并行报告基因功能筛选在菌群—宿主调控界面的应用，对做多组学功能注释的实验室有借鉴意义；但研究对象为肠道菌群与调控元件，与生殖医学、辅助生殖核心范畴几乎不交叉，仅可作为 omics/功能基因组方法学参考浏览。","keywords":["肠道菌群","调控元件","大规模并行报告基因分析","功能基因组学","宿主—微生物互作"],"selected":1,"story_id":217,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":2,"has_interpretation":false,"journal_key":"mol-cell","journal_tier":"cns-sub","journal_if":14.5,"is_mock":false,"summary_zh":"该文发表于 Molecular Cell（2026年5月7日，86卷1708–1722页），采用大规模并行报告基因功能鉴定策略，系统刻画肠道菌群对调控性 DNA 元件（启动子/增强子等）活性的调节。原文摘要信息有限，具体菌群来源、细胞模型、文库规模与验证方式未能获取；从标题与期刊定位判断，其为菌群—宿主基因调控界面的高通量功能图谱研究，方法学价值大于生殖医学直接价值。","summary":"(Molecular Cell 86, 1708–1722.e1–e9; May 7, 2026)","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}