{"id":517,"title":"Identification and regulation of an ACC1-associated lipogenic metabolon in liver","title_zh":"肝脏中ACC1相关脂肪生成代谢体的鉴定与调控","url":"https://doi.org/10.1016/j.molcel.2026.10.017","doi":"10.1016/j.molcel.2026.10.017","pmid":null,"journal":"Molecular Cell","kind":"paper","lang":"en","published_at":"2026-11-01T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Xiaotong Zhu","William B. McKean","Tam N.T. Tran","Xiaorong Fu","Shawn C. Burgess","Jay D. Horton","Chai-Wan Kim"],"primary_topic":"ethics-policy","topics":[{"slug":"ethics-policy","score":3.0,"hits":["regulation"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":42.0,"final_score":50.0,"score_dims":{"novelty":78,"rigor":70,"impact":15,"relevance":8,"translation":10},"recommend_reason":"该文聚焦肝脏ACC1代谢体与MASLD脂质代谢，机制新颖但属于肝脏代谢领域，与生殖医学、辅助生殖及胚胎多组学无直接关系，对ART读者参考价值有限。","keywords":["ACC1","脂肪生成代谢体","脂滴","MASLD","肝脏脂质代谢"],"selected":0,"story_id":218,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":2,"has_interpretation":false,"journal_key":"mol-cell","journal_tier":"cns-sub","journal_if":14.5,"is_mock":false,"summary_zh":"Zhu等报道了一个营养响应性的、以ACC1为核心的代谢体，可将脂质合成酶组织到脂滴附近，并与细胞内运输蛋白相关。在脂肪变性、胰岛素抵抗的肝脏中，ACC1相关相互作用增强，提示其可能成为调控肝脏脂质生成、干预MASLD的潜在靶点。原文摘要未提供样本量、具体实验体系与统计细节，严谨性需结合全文判断。","summary":"Zhu et al. identify a nutrient-responsive ACC1-centered metabolon that organizes lipid-synthesis enzymes near lipid droplets and associates with intracellular trafficking proteins. ACC1-associated interactions increase in steatotic, insulin-resistant livers, revealing a potential target for modulating hepatic lipid production in MASLD.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}