{"id":514,"title":"Altered protein cysteine reactivity in senescent cells is a vulnerability for senolysis to ameliorate aging","title_zh":"衰老细胞中蛋白半胱氨酸反应性改变可作为衰老细胞清除（senolysis）的脆弱靶点并改善衰老表型","url":"https://doi.org/10.1038/s43587-026-01253-5","doi":"10.1038/s43587-026-01253-5","pmid":null,"journal":"Nature Aging","kind":"paper","lang":"en","published_at":"2026-11-06T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Rong Wu","Fan Yang","Jiacheng Li","Tong Wu","Ruitu Lyu","Junhong Xiang","Xue Gao","Rukang Zhang","Hao Fan","Chunzhao Yin","Jiayi Tu","Zhicheng Xie","Chufan Cai","Freya Q. Zhang","Kelly Xue","Jeronimo Najarro","Lei Dong","Rui Su","Angelo Y. Meliton","Em Lundberg","Jonah K. Chen","Janane Rahbani","Nickolai O. Dulin","Nicole Arellano","Jun-Wei B. Hughes","Shannon E. Elf","Yu-Ying He","Bruce M. Bissonnette","Robert B. Hamanaka","Gökhan M. Mutlu","Judith Campisi","Chuan He","Jing Chen"],"primary_topic":"repro-aging","topics":[{"slug":"repro-aging","score":3.0,"hits":["senescent"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":62.0,"final_score":70.0,"score_dims":{"novelty":72,"rigor":60,"impact":55,"relevance":30,"translation":35},"recommend_reason":"从蛋白半胱氨酸反应性角度提出衰老细胞选择性清除的新脆弱点，机制思路新颖；但与生殖、胚胎及 ART 的直接关联较弱，属衰老生物学外围参考，对关注卵巢/生殖衰老的研究者有一定启发价值。","keywords":["细胞衰老","衰老细胞清除","半胱氨酸反应性","氧化还原","蛋白组学","衰老干预"],"selected":1,"story_id":13,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nat-aging","journal_tier":"cns-sub","journal_if":17.0,"is_mock":false,"summary_zh":"该研究发表于 Nature Aging，作者以衰老细胞为对象，系统分析蛋白半胱氨酸残基反应性的变化，发现衰老细胞在氧化还原与亲电应激相关半胱氨酸位点上呈现特征性改变，并据此提出可利用的分子脆弱性；通过靶向这些位点实现选择性清除衰老细胞（senolysis），在衰老模型中观察到衰老表型改善。原文未提供摘要，样本规模、模型体系、干预化合物及统计验证细节无法从可见信息判断，需查阅全文核实。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}