{"id":511,"title":"Circadian regulation of pancreatic islet function and the transcriptome by glucocorticoid signaling","title_zh":"糖皮质激素信号对胰腺胰岛功能及转录组的昼夜节律调控","url":"https://doi.org/10.1038/s41467-026-79151-y","doi":"10.1038/s41467-026-79151-y","pmid":null,"journal":"Nature Communications","kind":"paper","lang":"en","published_at":"2026-11-02T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Satish K. Sen","Matthew R. Brown","Liu Wang","Jie Wu","Luhui Zhang","Tracy Her","Kuntol Rakshit","Amelia Mazzone","Ananya Bharath","Alexandre Gaspar-Maia","Adrian Vella","Zong Wei","Aleksey V. Matveyenko"],"primary_topic":"ethics-policy","topics":[{"slug":"ethics-policy","score":3.0,"hits":["regulation"]},{"slug":"omics-methods","score":3.0,"hits":["transcriptome"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":34.0,"final_score":42.0,"score_dims":{"novelty":55,"rigor":45,"impact":30,"relevance":10,"translation":10},"recommend_reason":"主题是胰腺胰岛的昼夜节律与糖皮质激素调控，属于代谢内分泌方向，与本领域读者的核心需求（生殖内分泌、胚胎、ART 实验室）基本无关；且缺少摘要，无法评估方法与结论，不建议优先阅读。","keywords":["昼夜节律","糖皮质激素","胰岛功能","转录组","代谢内分泌"],"selected":0,"story_id":null,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nat-commun","journal_tier":"cns-sub","journal_if":14.7,"is_mock":false,"summary_zh":"该文发表于 Nature Communications，研究糖皮质激素信号如何昼夜节律性地调控胰腺胰岛功能与转录组。条目仅提供标题与作者，未给出摘要或正文，因此无法获知研究对象（人胰岛、小鼠模型或细胞系）、具体方法（转录组测序、条件性基因敲除、节律性采样等）、样本量、统计设计与关键结论。就现有信息判断，主题为胰岛内分泌生理与节律生物学，与生殖医学、辅助生殖及胚胎多组学无直接关联。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}