{"id":509,"title":"Rbpj restrains regulatory T cell exhaustion in tumors","title_zh":"Rbpj 抑制肿瘤中调节性 T 细胞的耗竭","url":"https://doi.org/10.1038/s41467-026-79069-5","doi":"10.1038/s41467-026-79069-5","pmid":null,"journal":"Nature Communications","kind":"paper","lang":"en","published_at":"2026-11-02T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Miranta Papadopoulou","Lampros Karkanis","Prabhakara R. Tharra","Myrto Mitletton","Apostolos Klinakis","Andrea Cossarizza","Aikaterini Hatzioannou","Mathieu Lavigne","Daniel P. Flaherty","Domenico Lo Tartaro","Panayotis Verginis"],"primary_topic":"repro-immunology","topics":[{"slug":"repro-immunology","score":3.0,"hits":["regulatory t cell"]},{"slug":"ethics-policy","score":3.0,"hits":["regulatory"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":42.0,"final_score":50.0,"score_dims":{"novelty":60,"rigor":50,"impact":20,"relevance":10,"translation":10},"recommend_reason":"该文主题为肿瘤免疫中 Treg 耗竭调控，与生殖/辅助生殖核心范畴关联很弱，且无摘要可供评估方法与结论；对生殖医学读者一般不建议优先阅读，仅对 Treg 生物学机制有交叉兴趣者可浏览。","keywords":["Rbpj","调节性T细胞","T细胞耗竭","肿瘤免疫","Treg"],"selected":0,"story_id":172,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nat-commun","journal_tier":"cns-sub","journal_if":14.7,"is_mock":false,"summary_zh":"该文发表于 Nature Communications，题名为 Rbpj restrains regulatory T cell exhaustion in tumors，作者为 Papadopoulou 等。原文未提供摘要，仅从标题可知研究关注 Rbpj 在肿瘤微环境中对调节性 T 细胞（Treg）耗竭的抑制作用，可能涉及 Treg 功能维持与抗肿瘤免疫调控。由于缺乏摘要与正文信息，无法确认研究对象、实验模型、关键方法、样本量及主要结论。就现有信息看，该文属于肿瘤免疫学基础研究，与生殖医学、辅助生殖及胚胎多组学的直接关联较弱。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}