{"id":505,"title":"Resident cardiac macrophage-like cells induced by an ILC2 cytokine cocktail confer cardioprotection through enhanced efferocytosis in a mouse model of myocardial infarction","title_zh":"ILC2细胞因子鸡尾酒诱导的心脏驻留巨噬细胞样细胞通过增强胞葬作用在小鼠心肌梗死模型中发挥心脏保护作用","url":"https://doi.org/10.1038/s41467-026-79157-6","doi":"10.1038/s41467-026-79157-6","pmid":null,"journal":"Nature Communications","kind":"paper","lang":"en","published_at":"2026-11-05T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Yongli Hou","Ziyan Chen","Yu He","Yuen Zeng","Ziye Hui","Yuchen He","Zhaoyue Fu","Ruiyan Liu","Yazhen Wang","Dingwen Shi","Kai Li","Liang Fang","Ying Ma","Jincheng Liu","Kang Tang","Lihua Chen"],"primary_topic":"repro-immunology","topics":[{"slug":"repro-immunology","score":3.0,"hits":["macrophage"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":32.0,"final_score":40.0,"score_dims":{"novelty":68,"rigor":55,"impact":20,"relevance":5,"translation":8},"recommend_reason":"内容为小鼠心梗模型的ILC2-巨噬细胞免疫机制研究，方法学思路（细胞因子诱导驻留巨噬细胞样细胞、胞葬作用）有一定新意，但研究器官与问题均不属生殖/辅助生殖/胚胎范畴，对ART实验室与临床决策无可直接迁移的价值，仅对关注母胎界面或子宫内膜巨噬细胞极化研究者提供类比性启发，故不推荐给本领域读者优先阅读。","keywords":["ILC2","心脏驻留巨噬细胞","胞葬作用","心肌梗死","细胞因子诱导","小鼠模型"],"selected":0,"story_id":null,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nat-commun","journal_tier":"cns-sub","journal_if":14.7,"is_mock":false,"summary_zh":"该研究在小鼠心肌梗死模型中，用ILC2（2型固有淋巴样细胞）相关细胞因子鸡尾酒诱导出具有心脏驻留巨噬细胞样表型的细胞，并发现这些细胞通过增强胞葬作用（efferocytosis，清除凋亡细胞）减轻心肌损伤、发挥心脏保护效应。原文平台未提供摘要，具体诱导方案、细胞来源、样本量与功能验证细节（如谱系追踪、敲除/过继转移实验、心功能指标）无法从现有信息确认，故方法学严谨性与结论强度只能待全文核实。研究主题属心血管免疫学，与生殖医学无直接关联。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}