{"id":503,"title":"Genomic language models decode bidirectional promoter activity and reveal conserved regulatory patterns across plant species","title_zh":"基因组语言模型解析双向启动子活性并揭示植物物种间保守调控模式","url":"https://doi.org/10.1038/s41467-026-79328-5","doi":"10.1038/s41467-026-79328-5","pmid":null,"journal":"Nature Communications","kind":"paper","lang":"en","published_at":"2026-11-05T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Shang Gao","Tingxi Yu","Jinran Wu","Shoukun Chen","Muhammad Amjad Farooq","Takele W. Gebrewahid","Jiahui Geng","Yuanyuan Jiang","Zhangping Huang","Jiankang Wang","Geoffrey J. McLachlan","Huihui Li"],"primary_topic":"ethics-policy","topics":[{"slug":"ethics-policy","score":3.0,"hits":["regulatory"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":36.0,"final_score":44.0,"score_dims":{"novelty":70,"rigor":45,"impact":20,"relevance":10,"translation":15},"recommend_reason":"不推荐生殖医学与辅助生殖读者优先阅读：主题为植物双向启动子与跨物种调控保守性，与生殖/胚胎核心范畴基本无关。仅对关注基因组语言模型方法学迁移的研究者有间接参考价值。","keywords":["基因组语言模型","双向启动子","植物","调控保守性","计算基因组学"],"selected":0,"story_id":null,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nat-commun","journal_tier":"cns-sub","journal_if":14.7,"is_mock":false,"summary_zh":"该研究发表于 Nature Communications（2026-11-05），标题显示其利用基因组语言模型解析双向启动子活性，并在不同植物物种间识别保守的调控模式。由于平台未提供摘要或正文，模型架构、训练数据、样本来源、验证方法与统计细节均无法核实。从标题判断，该工作属于植物基因调控与计算方法学研究，未涉及生殖医学、辅助生殖或胚胎研究；具体结论需以原文为准。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}