{"id":502,"title":"Non-canonical FOXO1 signaling governs epithelial barrier integrity through spatial regulation of the E-cadherin–β-catenin complex","title_zh":"非经典 FOXO1 信号通过空间调控 E-cadherin–β-catenin 复合体维持上皮屏障完整性","url":"https://doi.org/10.1038/s41467-026-78640-4","doi":"10.1038/s41467-026-78640-4","pmid":null,"journal":"Nature Communications","kind":"paper","lang":"en","published_at":"2026-11-06T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Stella Alimperti","Peter Lialios","Minjung Kim","Rahul Patil","Sana Surrency","Alison Grafton","Yu Jung Heo","Noor Fatima","Minkyu Kim","Eun-Jin Lee","Dana T. Graves"],"primary_topic":"ethics-policy","topics":[{"slug":"ethics-policy","score":3.0,"hits":["regulation"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":42.0,"final_score":50.0,"score_dims":{"novelty":63,"rigor":52,"impact":30,"relevance":22,"translation":18},"recommend_reason":"属于上皮细胞生物学与细胞黏附信号的基础机制研究，FOXO1 非经典信号与 E-cadherin–β-catenin 空间调控的结论对上胚层/滋养层上皮生物学或有间接启发，但本条目无摘要、无生殖相关实验背景，与生殖医学和 ART 临床相距较远，仅建议关注上皮屏障机制者按需浏览。","keywords":["FOXO1","E-cadherin","β-catenin","上皮屏障","细胞黏附","非经典信号"],"selected":0,"story_id":15,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nat-commun","journal_tier":"cns-sub","journal_if":14.7,"is_mock":false,"summary_zh":"该文发表于 Nature Communications，题为非经典 FOXO1 信号通过空间调控 E-cadherin–β-catenin 复合体决定上皮屏障完整性。由于检索条目未提供摘要与正文，仅从标题可知研究聚焦 FOXO1 的非经典（非转录依赖）信号功能，及其对 E-cadherin–β-catenin 黏附复合体亚细胞定位与上皮屏障功能的调控。具体实验体系（细胞类型、动物模型）、样本量、机制细节与验证手段均无法从现有信息判断，需查阅原文确认；文中亦未出现生殖、胚胎或子宫内膜等直接相关的实验背景。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}