{"id":500,"title":"Propofol induces sustained suppression of alcohol drinking via habenular activation in mice","title_zh":"丙泊酚经缰核激活在小鼠中持续抑制饮酒行为","url":"https://doi.org/10.1038/s41467-026-79118-z","doi":"10.1038/s41467-026-79118-z","pmid":null,"journal":"Nature Communications","kind":"paper","lang":"en","published_at":"2026-11-07T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Zheng Xu","Zhi-Jie Fan","Yi Mei","Yu-Mei Yu","Chao-chao Zhong","Qi Li","Xinran Zhuang","Lijuan Wang","Dongyu Zhou","Chen Zhu","Jun-Xia Yang","Hai-Lei Ding","Zhe Zhang","Song Zhang","Jun-Li Cao"],"primary_topic":"repro-tox","topics":[{"slug":"repro-tox","score":3.0,"hits":["alcohol"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":40.0,"final_score":48.0,"score_dims":{"novelty":55,"rigor":35,"impact":12,"relevance":8,"translation":10},"recommend_reason":"主题为丙泊酚的神经药理学与酒精成瘾行为，与生殖医学和 ART 核心范畴无直接关联；且缺少摘要和方法细节，不建议本领域读者优先阅读。","keywords":["丙泊酚","缰核","酒精摄入","小鼠","神经药理学"],"selected":0,"story_id":null,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nat-commun","journal_tier":"cns-sub","journal_if":14.7,"is_mock":false,"summary_zh":"该条目报道了一项发表于 Nature Communications 的小鼠研究，标题提示丙泊酚可通过激活缰核产生对饮酒行为的持续抑制。原文未提供摘要，样本量、给药方案、行为学范式、对照设置、统计方法和机制验证细节均无法核验。就可见信息而言，研究主题属于神经药理学与成瘾行为学，而非生殖医学、辅助生殖或胚胎多组学核心范畴，因此对本领域读者的直接参考价值有限。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}