{"id":496,"title":"Fatty acid desaturation controls cellular fate decisions between senescence and ferroptosis","title_zh":"脂肪酸去饱和决定细胞在衰老与铁死亡之间的命运选择","url":"https://doi.org/10.1016/j.cell.2026.09.036","doi":"10.1016/j.cell.2026.09.036","pmid":null,"journal":"Cell","kind":"paper","lang":"en","published_at":"2026-11-01T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Chisaka Kuehnemann","Samantha T. Jezak","Bronwyn A. Mogck","Niharika Kura","Rushmeen Tariq","Yuheng Che","Maija Vaittinen","Ioannis Siokas","Sharvari Deshpande","Carlyn Guthrie","Xuejuan Tan","Eliezer Aimontche","Aleksandra Aljakna Kahn","Peter Reifsnyder","Gung Lee","Amene Majidipur","Andrew H. Kung","Qiaoling Wang","Diana Jurk","Tong Zheng","Andrew S. Greenberg","Xiang-Dong Wang","Koji Kitazawa","Gregory Dolnikowski","Yong Cheng","Nirupa R. Matthan","Arvind Ramanthan","Jennifer Lee","Daniel Roh","Howard H. Chen","Jussi Pihlajamaki","Ron Korstanje","Christopher D. Wiley"],"primary_topic":"repro-aging","topics":[{"slug":"repro-aging","score":3.0,"hits":["senescence"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":64.0,"final_score":76.0,"score_dims":{"novelty":72,"rigor":62,"impact":52,"relevance":38,"translation":38},"recommend_reason":"以 DGLA 为枢纽，把脂质去饱和代谢与衰老和铁死亡这两种命运程序直接联系起来，机制视角新颖，对理解卵巢衰老与卵泡微环境中的细胞命运失衡有潜在启发；但当前仅为要点式摘要，未见生殖相关模型，属于间接相关的基础细胞生物学进展，值得浏览而非必读。","keywords":["DGLA","脂肪酸去饱和","铁死亡","细胞衰老","脂质过氧化","细胞命运决定"],"selected":1,"story_id":221,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":2,"has_interpretation":false,"journal_key":"cell","journal_tier":"cns","journal_if":45.5,"is_mock":false,"summary_zh":"该研究（Cell，2026-11-01，Crossref 上线信息）聚焦多不饱和脂肪酸代谢对细胞命运决定的调控。据可见摘要，二高-γ-亚麻酸（DGLA）的缺失使细胞倾向进入衰老状态，而补充 DGLA 则转而触发铁死亡，提示脂肪酸去饱和通路是决定细胞在衰老与铁死亡之间命运选择的关键节点。目前公开信息仅为要点式摘要，具体细胞模型（是否涉及生殖细胞、颗粒细胞或胚胎）、实验设计与分子机制（如脂质过氧化与去饱和酶调控）尚未披露，需查阅全文核实。","summary":"Polyunsaturated fatty acid metabolism shapes cell fate decisions: loss of DGLA favors senescence, whereas DGLA repletion triggers ferroptosis.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}