{"id":491,"title":"In Vivo CRISPR Base Editing of ANGPTL3 for Durable Lipid Lowering","title_zh":"体内CRISPR碱基编辑ANGPTL3实现持久降脂","url":"https://doi.org/10.1038/s41586-026-11233-9","doi":"10.1038/s41586-026-11233-9","pmid":null,"journal":"Nature","kind":"paper","lang":"en","published_at":"2026-11-06T00:00:00+00:00","fetched_at":"2026-11-08T03:45:21+00:00","authors":["Taiji Mizoguchi","Jamie E. DeNizio","Alexandra C. Chadwick","Anne Marie Mazzola","Maxwell P. Brown","Shashank Mishra","Manashree Damle","Yuri Matsumoto","Victoria Neang","Ryan Garrity","Manini Mantri","Joy Oshoname Olorife","Hui-Ting Hsu","Vian Peshdary","Estela Shabani","John D. Ganey","Ryan Santos","Anthony Federico","Sara P. Garcia","Pengying Hao","Yue Wu","Zachary Glass","Lisa N. Kasiewicz","Caroline Summers","Athul Sanjeev","Kui Wang","Steven D. Briscoe","Robert S. Rosenson","Christopher J. Cheng","Ellen Rohde","Joseph Biedenkapp","Victor Farutin","Andrew M. Bellinger","Kiran Musunuru","Sekar Kathiresan","Troy Lister","Kallanthottathil G. Rajeev","Richard G. Lee","Amit V. Khera"],"primary_topic":"ethics-policy","topics":[{"slug":"ethics-policy","score":3.0,"hits":["crispr"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":35.0,"final_score":47.0,"score_dims":{"novelty":78,"rigor":55,"impact":20,"relevance":8,"translation":15},"recommend_reason":"该研究属于体细胞基因编辑降脂治疗，技术路线有新意，但与生殖医学和胚胎研究核心范畴无关；仅在关注基因编辑监管、伦理边界或技术外溢时值得浏览。","keywords":["CRISPR碱基编辑","ANGPTL3","体内基因编辑","降脂治疗","体细胞编辑"],"selected":0,"story_id":null,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-cns","source_name":"Crossref · CNS 与大子刊新上线（领域过滤）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nature","journal_tier":"cns","journal_if":50.5,"is_mock":false,"summary_zh":"该条目为Nature上线论文，报道采用体内CRISPR碱基编辑靶向ANGPTL3以实现持久性血脂降低，作者包括Mizoguchi等，发表时间为2026-11-06。由于条目未提供摘要或正文，无法获知研究模型、给药方式、编辑效率、安全性评估、样本量及随访时长等关键信息；仅从标题可判断其为体细胞基因编辑治疗高脂血症的研究，与生殖医学、辅助生殖及胚胎多组学无直接关系。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}