{"id":486,"title":"Anti-Müllerian hormone protects human ovarian follicles and stroma from cyclophosphamide-induced DNA damage and apoptosis in vitro","title_zh":"抗苗勒管激素在体外可保护人卵巢卵泡及间质免受环磷酰胺诱导的DNA损伤与凋亡","url":"https://doi.org/10.1016/j.rbmo.2026.106066","doi":"10.1016/j.rbmo.2026.106066","pmid":null,"journal":"Reproductive BioMedicine Online","kind":"paper","lang":"en","published_at":"2026-11-01T00:00:00+00:00","fetched_at":"2026-11-08T03:44:35+00:00","authors":["Emily B Walshe","Tara S Best","Hazel L Stewart","Evelyn E Telfer","Richard A Anderson","Roseanne Rosario"],"primary_topic":"oocyte","topics":[{"slug":"oocyte","score":6.0,"hits":["follicles","ovarian"]},{"slug":"repro-endo","score":3.0,"hits":["anti-müllerian"]}],"topic_score":6.0,"preference_score":0.0,"preference_labels":[],"llm_score":74.0,"final_score":74.0,"score_dims":{"novelty":72,"rigor":60,"impact":76,"relevance":92,"translation":70},"recommend_reason":"选题直接关联化疗相关卵巢毒性防护与生育力保存，AMH的局部保护作用具有潜在转化价值；但缺少摘要，严谨性和结论强度需查全文后判断。","keywords":["抗苗勒管激素","人卵巢卵泡","环磷酰胺","DNA损伤","凋亡","生育力保存"],"selected":1,"story_id":223,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-core-journals","source_name":"Crossref · 核心期刊新上线","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"rbmo","journal_tier":"standard","journal_if":3.7,"is_mock":false,"summary_zh":"该文探讨抗苗勒管激素（AMH）在体外对人卵巢卵泡和间质的保护作用，针对化疗药环磷酰胺诱导的DNA损伤与凋亡。根据标题可知研究采用人卵巢组织体外实验，观察AMH对卵泡及间质细胞DNA损伤和凋亡的影响。原文未提供摘要，具体样本量、实验设计、检测指标及统计学结果无法核实；结论倾向于AMH可能减轻环磷酰胺对卵巢的毒性，但需阅读全文确认。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}