{"id":483,"title":"Prevalence of rare autosomal aneuploidies in pregnancies following assisted reproduction: a retrospective study","title_zh":"辅助生殖妊娠中罕见常染色体非整倍体的发生率：一项回顾性研究","url":"https://doi.org/10.1016/j.rbmo.2026.106064","doi":"10.1016/j.rbmo.2026.106064","pmid":null,"journal":"Reproductive BioMedicine Online","kind":"paper","lang":"en","published_at":"2026-11-01T00:00:00+00:00","fetched_at":"2026-11-08T03:44:35+00:00","authors":["Andreas Debeuckelaere","Olga Tsuiko","Leen Vancoillie","Sophie Debrock","Karen Peeraer","Hilde Van Esch","Joris Robert Vermeesch","Eftychia Dimitriadou","Arne Vanhie"],"primary_topic":"art-clinical","topics":[{"slug":"art-clinical","score":3.0,"hits":["assisted reproduction"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":70.0,"final_score":70.0,"score_dims":{"novelty":62,"rigor":60,"impact":65,"relevance":90,"translation":72},"recommend_reason":"RAA属于常规核型与PGT-A之外的“盲区”，直接关系到ART妊娠的产前筛查与遗传咨询策略；问题清晰、临床相关度高，但为回顾性设计且摘要信息有限，需阅读全文再评估证据强度。","keywords":["罕见常染色体非整倍体","辅助生殖技术","产前遗传筛查","染色体微阵列","回顾性队列"],"selected":1,"story_id":226,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-core-journals","source_name":"Crossref · 核心期刊新上线","source_tier":1,"mention_count":2,"has_interpretation":false,"journal_key":"rbmo","journal_tier":"standard","journal_if":3.7,"is_mock":false,"summary_zh":"该研究针对“辅助生殖技术（ART）妊娠相比自然妊娠，罕见常染色体非整倍体（RAA）的相对风险是否升高”这一临床问题，采用回顾性设计，在ART妊娠队列中系统评估RAA的发生情况，并与自然妊娠对照比较。作者团队来自鲁汶大学等机构，研究发表于《Reproductive BioMedicine Online》。目前可见文本仅包含研究问题，未披露样本量、RAA检测手段（如染色体微阵列或核型分析）、具体发生率数值及统计校正方式；因此，结论应表述为：研究旨在为ART妊娠的产前遗传筛查策略提供风险数据，但摘要层面的结果尚无法核实。","summary":"Is there a higher relative risk of rare autosomal aneuploidies (RAA) in assisted reproductive technique (ART) pregnancies compared with naturally conceived pregnancies?","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}