{"id":480,"title":"Microfluidic sperm sorting versus double density gradient centrifugation in donor oocyte cycles: retrospective comparative study","title_zh":"微流控精子分选与双密度梯度离心在供卵周期中的回顾性比较研究","url":"https://doi.org/10.1016/j.rbmo.2026.106071","doi":"10.1016/j.rbmo.2026.106071","pmid":null,"journal":"Reproductive BioMedicine Online","kind":"paper","lang":"en","published_at":"2026-11-01T00:00:00+00:00","fetched_at":"2026-11-08T03:44:35+00:00","authors":["Suneetha Samarasi","Krishna Chaitanya Mantravadi","Durga Gedela Rao","Kesavulu Muppuru Muni","Huidrom Yaiphaba Meitei"],"primary_topic":"oocyte","topics":[{"slug":"oocyte","score":3.0,"hits":["oocyte"]},{"slug":"male","score":3.0,"hits":["sperm"]},{"slug":"art-clinical","score":3.0,"hits":["donor oocyte"]},{"slug":"embryology-lab","score":3.0,"hits":["microfluidic"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":68.0,"final_score":68.0,"score_dims":{"novelty":66,"rigor":55,"impact":62,"relevance":92,"translation":72},"recommend_reason":"供卵周期设计可在一定程度上控制卵子质量混杂因素，直接回答“无指征时是否常规使用MFSS”这一实验室现实问题，对精子处理流程决策有参考价值；但目前仅见研究问题，样本量与结局数据未公开，证据强度有限，宜待全文发表后再评判。","keywords":["微流控精子分选","双密度梯度离心","供卵周期","精子处理","辅助生殖结局","normozoospermia"],"selected":1,"story_id":229,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"crossref-core-journals","source_name":"Crossref · 核心期刊新上线","source_tier":1,"mention_count":2,"has_interpretation":false,"journal_key":"rbmo","journal_tier":"standard","journal_if":3.7,"is_mock":false,"summary_zh":"该研究为回顾性比较研究，纳入男性配偶精液参数正常（normozoospermia）的供卵辅助生殖周期，比较常规使用微流控精子分选（MFSS）与双密度梯度离心（DDG）是否带来生殖结局优势，核心问题是：在无特定临床指征时，是否应常规采用MFSS。目前可获取的仅为研究问题与设计框架，样本量、分组方式、主要结局（受精率、优质胚胎率、临床妊娠与活产等）及统计结果尚未披露，故无法判断两种精子处理方式的优劣。该研究的价值在于以供卵周期作为“去卵源异质性”的模型，检验常规MFSS的必要性。","summary":"Does routine use of microfluidic sperm sorting (MFSS), in the absence of a specific clinical indication offer reproductive advantages over double density gradient (DDG) centrifugation in donor oocyte assisted reproductive technology (ART) cycles involving normozoospermic male partners?","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}