{"id":471,"title":"Endosperm secretion remodels the maternal seed coat","title_zh":"胚乳分泌细胞壁松弛蛋白重塑母本种皮：拟南芥中亲本表观遗传调控母胎界面扩张的新机制","url":"https://doi.org/10.64898/2026.10.26.762064","doi":"10.64898/2026.10.26.762064","pmid":null,"journal":"bioRxiv","kind":"preprint","lang":"en","published_at":"2026-10-29T00:00:00+00:00","fetched_at":"2026-11-08T03:44:14+00:00","authors":["Yang K","Guo W","Tang Y","Li Y","Zhu Y","Xi X","Meng M","Wang Z","Axelsson E","Ye H","Xia C","Xie W","Yao J","Zhu Y","Lü P","Zhao P","Sun M","Berger F","Xu R","Li J"],"primary_topic":"repro-genetics","topics":[{"slug":"repro-genetics","score":1.0,"hits":["dna methylation"]}],"topic_score":1.0,"preference_score":0.0,"preference_labels":[],"llm_score":56.0,"final_score":56.0,"score_dims":{"novelty":82,"rigor":76,"impact":40,"relevance":22,"translation":15},"recommend_reason":"机制新颖：揭示了胚乳通过分泌扩展蛋白远程重塑母本种皮的跨代表观调控，对理解母胎界面与亲本冲突有概念启发；但研究对象为植物种子，与人类生殖和 ART 临床距离很远，仅适合对跨代表观遗传调控感兴趣的读者浏览。","keywords":["胚乳","种皮","扩展蛋白","细胞壁松弛","亲本表观遗传","HAIKU-WRKY10"],"selected":0,"story_id":283,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"europepmc-preprints","source_name":"Europe PMC · 预印本（领域内）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"biorxiv","journal_tier":"standard","journal_if":null,"is_mock":false,"summary_zh":"该预印本以拟南芥为材料，研究胚乳如何影响包裹它的母本种皮。作者发现，调控种子大小的 HAIKU–WRKY10 通路激活胚乳分泌程序，产生富含细胞壁相关蛋白的分泌物；这些蛋白经共享的胞外区域扩散至多层内种皮，使胚乳能作用于并不直接接触的母本细胞。其中三种扩展蛋白（expansin）对母本细胞伸长与种子生长既必要又充分。父本 DNA 甲基化与母本 Polycomb 活性共同调控该程序，Polycomb 还负责及时关闭扩展蛋白表达。研究提示，后代通过分泌蛋白驱动母本组织扩张，与哺乳动物胚外组织的表观遗传信号策略相似。","summary":"Summary In flowering plants and mammals, maternal tissues must accommodate the growth of the offspring they enclose. The maternal seed coat expands around the developing embryo and endosperm. Endosperm pressure and hormonal signals coordinate seed-coat development 1,2, but whether the endosperm directly promotes maternal cell elongation remains unclear. Here we show that the coenocytic Arabidopsis endosperm directly supplies cell-wall-loosening proteins to maternal seed-coat walls. The seed-size-regulating HAIKU–WRKY10 pathway activates an endosperm secretory programme enriched in cell-wall-associated proteins. These proteins spread through a shared extracellular domain across multiple inner seed-coat layers, revealing an extensive functional maternal–filial interface through which the endosperm reaches maternal cells it does not directly contact. Among these proteins, three expansins are necessary and sufficient for maternal cell elongation and seed growth. The endosperm therefore promotes its own growth by enabling expansion of the maternal tissues that enclose it. Paternal DNA methylation and maternal Polycomb activity jointly regulate this programme, with Polycomb also required for timely shutdown of expansin expression. These findings link parental epigenetic states to maternal tissue expansion through proteins supplied by the offspring. This cross-generational control of growth parallels epigenetically regulated signaling from mammalian extraembryonic tissues 3, suggesting a shared strategy for adapting the maternal environment to offspring development.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}