{"id":468,"title":"Reproductive Choices and Family-building Decision Uncertainty Among Young Women at Familial Risk for Breast Cancer","title_zh":"乳腺癌家族史高风险年轻女性的生育选择与家庭组建决策不确定性","url":"https://doi.org/10.21203/rs.3.rs-10935505/v1","doi":"10.21203/rs.3.rs-10935505/v1","pmid":null,"journal":"Research Square","kind":"preprint","lang":"en","published_at":"2026-10-30T00:00:00+00:00","fetched_at":"2026-11-08T03:44:14+00:00","authors":["Davis AM","Reese JB","John EM","Kurian AW","Ford JS","Andrulis IL","Colonna SV","Daly MB","Genkinger J","Southey MC","Terry MB","Benedict C"],"primary_topic":"repro-genetics","topics":[{"slug":"art-clinical","score":1.0,"hits":["surrogacy"]}],"topic_score":1.0,"preference_score":0.0,"preference_labels":[],"llm_score":57.0,"final_score":57.0,"score_dims":{"novelty":55,"rigor":62,"impact":45,"relevance":55,"translation":50},"recommend_reason":"选题贴近遗传性肿瘤风险人群的生育决策与胚胎遗传学检测咨询场景，N=471样本量尚可，可为生殖遗传咨询与决策辅助工具设计提供依据；但属横断面自评问卷、预印本，无ART结局数据，与实验室/临床操作层面关联有限，宜作背景阅读。","keywords":["乳腺癌家族史","生育决策不确定性","家庭组建","遗传风险认知","决策支持","胚胎遗传学检测"],"selected":0,"story_id":257,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"europepmc-preprints","source_name":"Europe PMC · 预印本（领域内）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"research-square","journal_tier":"standard","journal_if":null,"is_mock":false,"summary_zh":"研究基于乳腺癌家族登记库（BCFR）年轻女性研究，对471名18–45岁有乳腺癌家族史的妇女进行了横断面调查。约58.6%尚无子女，47.8%希望未来生育，16.6%不确定；有兴趣或不确定者（n=303）中85.8%考虑自然受孕，但对胚胎遗传学检测、供卵/供精、代孕和收养等选项多不确定。43%–57%存在不同程度的决策不确定性，对遗传癌症风险和家庭组建选项的自评知识普遍偏低。最终模型显示，无妊娠史、德系犹太人身份、担忧未来子女健康且不关注生育时间表、知识水平较低，均与更高的决策不确定性相关。结论认为，该人群决策不确定性普遍存在，受健康顾虑、知识缺口、经济障碍与价值观影响，提示需要开展有针对性的决策支持干预。","summary":"Abstract Background: A family history of breast cancer may impact reproductive choices and decisions about family-building. This study evaluated family-building considerations, plans, and decisional processes among women with a breast cancer family history, and examined sociodemographic, clinical, and psychosocial factors related to decision uncertainty. Methods: Cross-sectional data from the Breast Cancer Family Registry (BCFR) Young Women’s Study were analyzed. Participants were women (18-45 years old) with a breast cancer family history. They completed questionnaires including a Reproductive Choices module. Bivariate analyses and multiple regression evaluated relationships among study variables. Results: Participants (N=471) were on average 30.3 years old (SD=6.7), predominantly non-Hispanic White (75.1%), and over half were childless (58.6%); nearly half (47.8%) desired future children, 16.6% were unsure, and 35.7% did not. Among those interested/unsure (n=303), most considered natural conception (85.8%); many were unsure about alternative options such as embryo genetic testing, donor gametes, surrogacy, and adoption. Between 43–57% endorsed some degree of decision uncertainty. Perceived knowledge about genetic cancer risk and family-building options appeared low overall. In the final model, greater decision uncertainty was associated with having no history of pregnancy, identifying as Ashkenazi Jewish, endorsing concern about a future child's health, lack of concern about family-building timeline, and lower perceived knowledge about genetic cancer risk and family-building options. Conclusions: Among women with a familial risk for breast cancer, decision uncertainty about family-building options is prevalent and is driven by health-related concerns, knowledge gaps, financial barriers, and values-based considerations. Findings can inform targeted decision support interventions for this population.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}