{"id":458,"title":"CortexQ Predictive Immune Escape Interception Across Pathway and Molecular Scales","title_zh":"CortexQ：跨通路与分子尺度的免疫逃逸预判与拦截计算框架（以结直肠癌为主、提出子宫内膜应用设想）","url":"https://doi.org/10.21203/rs.3.rs-11513282/v1","doi":"10.21203/rs.3.rs-11513282/v1","pmid":null,"journal":"Research Square","kind":"preprint","lang":"en","published_at":"2026-11-01T00:00:00+00:00","fetched_at":"2026-11-08T03:44:14+00:00","authors":["Soto G"],"primary_topic":"ai-compute","topics":[{"slug":"endometrium","score":1.0,"hits":["endometrial"]}],"topic_score":1.0,"preference_score":0.0,"preference_labels":[],"llm_score":36.0,"final_score":36.0,"score_dims":{"novelty":62,"rigor":30,"impact":18,"relevance":12,"translation":12},"recommend_reason":"方法学思路（证伪条件化的跨尺度干预决策）有一定新意，但主体是肿瘤免疫逃逸与计算肿瘤学，与生殖医学/ART 仅有一句未经验证的子宫内膜应用设想，且证据均为组件级、部分结果噪声主导，对生殖领域读者实用价值很低。","keywords":["免疫逃逸预测","证伪条件化计算","耐药拦截","功能性口袋动力学","量子计算辅助","子宫内膜应用设想"],"selected":0,"story_id":null,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"europepmc-preprints","source_name":"Europe PMC · 预印本（领域内）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"research-square","journal_tier":"standard","journal_if":null,"is_mock":false,"summary_zh":"该预印本介绍 CortexQ 计算框架，用「证伪条件化」策略在通路与分子两个尺度上预判肿瘤免疫恢复、逃逸与耐药拦截策略：QEPD 提供干预条件下的通路预测，SPE 用已知耐药解释与扰动证据检验逃逸假设，功能性口袋动力学把分析延伸到蛋白运动构象。研究以结直肠癌（CortexQ-CRC-01）为主场景，并提出向子宫内膜转移场景（CortexQ-EC-01）的设想，但未见相应数据。报告结果为组件级进展：回顾性基准 AP 0.8347 对比参考 0.7832（比较条件受限）、4 例患者 11 个状态转换的纵向原型准确率 0.5455、分子原型与量子设备结果受噪声主导（结构演示为构造性）。作者明确指出整合性预测优势、分子效力与实用量子加速仍需单独评估。","summary":"Abstract CortexQ develops a computational method for anticipating immune recovery, subsequent tumor escape and molecular strategies for intercepting resistance. QEPD supplies intervention-conditioned pathway forecasts. SPE challenges escape hypotheses using known resistance explanations and perturbation evidence. Functional Pocket Dynamics extends the investigation to molecular behavior across protein motion. The proposed and tested invention connects these pathway and structural challenges to a common intervention decision, with explicit treatment of uncertainty, contradictory evidence and unavailable measurements. CortexQ-CRC-01 supplies the lead colorectal research setting. CortexQ-EC-01 supplies a proposed endometrial transfer setting. The candidate technical contribution is a disproof-conditioned computation across pathway and molecular scales. Here, disproof conditioning challenges candidate behavior against credible known explanations. A forecast identifies resistance to challenge, functional evidence tests persistence under independent route blockade, and structural evidence tests whether a molecular opportunity survives known-motion explanations. Compatible results inform a ranked research hypothesis. Missing required evidence identifies the experiment needed next. Recorded outcomes are intended to update biological models and subsequent research strategies through controlled training and evaluation. Quantum-assisted molecular hypothesis acceleration is a supporting research direction. Development records include retrospective colorectal gene recovery, a revised perturbation layer, preliminary longitudinal state prediction, molecular prototypes and quantum hardware execution. An archived post-repair relevance benchmark reports AP 0.8347 versus 0.7832 for its reference, with unresolved comparison restrictions. A longitudinal prototype reports accuracy 0.5455 on eleven held-out state-change transitions from four patients. Structural demonstrations are constructed, and the reported quantum-device result was noise dominated. These results document component progress. Integrated predictive superiority, molecular efficacy and practical quantum advantage require separate evaluation.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}