{"id":444,"title":"A null adult postmortem-brain test of a locked 468-gene panel in autism spectrum disorder, with published maternal-axis architecture as context","title_zh":"成人死后脑组织中锁定468基因panel的孤独症谱系障碍检验：阴性结果与已发表的母源轴构架作为背景","url":"https://doi.org/10.21203/rs.3.rs-11553062/v1","doi":"10.21203/rs.3.rs-11553062/v1","pmid":null,"journal":"Research Square","kind":"preprint","lang":"en","published_at":"2026-11-03T00:00:00+00:00","fetched_at":"2026-11-08T03:44:14+00:00","authors":["McCaulley ME"],"primary_topic":"repro-genetics","topics":[],"topic_score":0.0,"preference_score":0.0,"preference_labels":[],"llm_score":32.0,"final_score":32.0,"score_dims":{"novelty":42,"rigor":48,"impact":20,"relevance":12,"translation":15},"recommend_reason":"该研究用成人死后脑组织对预先锁定的基因panel做验证，方法学上较规范，结果也偏向阴性；但其对象是ASD神经病理，不涉及配子、胚胎、子宫内膜或ART临床决策，与生殖医学核心范畴关联极弱，对本领域读者优先级低。","keywords":["孤独症谱系障碍","死后脑组织","锁定基因panel","meta分析","母源免疫激活","转录组"],"selected":0,"story_id":null,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"europepmc-preprints","source_name":"Europe PMC · 预印本（领域内）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"research-square","journal_tier":"standard","journal_if":null,"is_mock":false,"summary_zh":"作者在四个成人死后脑GEO队列（GSE102741、GSE28521、GSE269105、GSE64018）中，用预先锁定、未做调整的468个基因panel（涉及氧化还原、金属、异源物质与屏障功能）检验孤独症谱系障碍（ASD）。采用DerSimonian–Laird逆方差随机效应meta分析，392个基因可分析；摘要在此处被截断，仅显示“其中一个基因在Benjamini–Hochberg FDR……”处中断，完整效应量与结论无法获知。可判断的是：这是一项以已发表母源免疫/母源轴构架为背景的成人脑组织验证性分析，样本为死后成人脑，与围产期及母源因素仅有间接关联。","summary":"Abstract Autism spectrum disorder (ASD) was examined in four primary adult postmortem-brain GEO cohorts (GSE102741, GSE28521, GSE269105, GSE64018) using a frozen 468-gene redox, metal, xenobiotic, and barrier panel. Inverse-variance random-effects meta-analysis (DerSimonian–Laird) produced 392 analyzable genes, one at Benjamini–Hochberg FDR","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}