{"id":431,"title":"Gene regulation at the early human maternal-fetal interface","title_zh":"早期人类母胎界面的基因调控","url":"https://pubmed.ncbi.nlm.nih.gov/42864449","doi":"10.1038/s41576-026-01014-5","pmid":"42864449","journal":"Nat Rev Genet","kind":"paper","lang":"en","published_at":"2026-10-12T00:00:00+00:00","fetched_at":"2026-11-08T03:44:13+00:00","authors":["Paredes A","Kim CE","Vento-Tormo R"],"primary_topic":"endometrium","topics":[{"slug":"endometrium","score":6.0,"hits":["maternal-fetal interface","placental","trophoblast"]},{"slug":"ethics-policy","score":4.0,"hits":["regulation"]},{"slug":"early-pregnancy","score":1.0,"hits":["pregnancy outcomes"]},{"slug":"omics-methods","score":1.0,"hits":["single-cell"]}],"topic_score":6.0,"preference_score":0.0,"preference_labels":[],"llm_score":82.0,"final_score":90.0,"score_dims":{"novelty":75,"rigor":80,"impact":85,"relevance":85,"translation":70},"recommend_reason":"由顶尖综述期刊组织，系统整合单细胞/空间组学在母胎界面与滋养层调控中的最新证据，可为植入与早期妊娠研究及体外模型设计提供框架性参考；但属综述，无原始数据，转化落地需结合具体研究。","keywords":["母胎界面","滋养层细胞","单细胞与空间组学","基因调控","胎盘发育","体外模型"],"selected":1,"story_id":413,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-top-journals","source_name":"PubMed · CNS/大子刊/四大医学刊（生殖相关）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nrg","journal_tier":"cns-sub","journal_if":39.1,"is_mock":false,"summary_zh":"本文为Nat Rev Genet综述，聚焦妊娠早期母胎界面的基因调控。作者指出，健康妊娠依赖胎盘发育，胎儿基因型的特化滋养层细胞驱动母胎界面形成；该界面既能支持胎儿发育，又能维护母体健康。文章系统梳理了单细胞、单核与空间基因组学及数据科学进展如何揭示滋养层分化调控，及其在调节免疫、重塑血管、与母体细胞通讯中的作用；并结合体外模型，讨论推断基因组调控、细胞行为与妊娠稳态因果机制的前景。原文为综述，未提供原始数据与具体样本量。","summary":"Pregnancy is a distinct physiological context in which the mother hosts and nurtures the development of a genetically distinct fetus. Healthy pregnancy outcomes rely on successful placental development, during which specialized placental cells with fetal genotype, known as trophoblasts, drive the establishment of the maternal-fetal interface, a balanced tissue ecosystem that supports fetal development while safeguarding maternal well-being. Advances in single-cell, single-nuclei and spatial genomics technologies, along with data science, are now providing an unprecedented view of trophoblast regulation, which drives their differentiation into diverse cell subtypes that dynamically transform the maternal niche. More specifically, these cells modulate the immune system and remodel the vasculature to facilitate communication with maternal cells, leading to the successful formation of the maternal-fetal interface. These advances, when combined with in vitro modelling, hold promise for inferring causality in mechanisms that govern genome regulation, cellular behaviour and ultimately pregnancy homeostasis and maladaptive responses.","interpretation_basis":null,"fulltext_status":"non_oa","interpretation":null,"fulltext":{"available":false,"status":"non_oa","reason":"Europe PMC 未收录免费全文（非 OA，或该来源不在 Europe PMC 全文范围内，如 bioRxiv 预印本）：isOpenAccess=False, inEPMC=False","pmcid":null,"license":null,"chars":0,"source":"Europe PMC","fetched_at":"2026-11-08T04:16:17+00:00"}}