{"id":409,"title":"Transcriptional control of meiotic recombination by DREAM complex components","title_zh":"DREAM复合物组分对减数分裂重组的转录调控","url":"https://pubmed.ncbi.nlm.nih.gov/42886811","doi":"10.1126/sciadv.aef2922","pmid":"42886811","journal":"Sci Adv","kind":"paper","lang":"en","published_at":"2026-10-16T00:00:00+00:00","fetched_at":"2026-11-08T03:44:12+00:00","authors":["Tunçay H","Ma X","Müller K","Guo Y","Toccaceli VF","Fu H","Böwer F","Lang L","Latrasse D","Wang Y","Benhamed M","Schnittger A"],"primary_topic":"oocyte","topics":[{"slug":"oocyte","score":4.0,"hits":["meiotic"]},{"slug":"repro-genetics","score":4.0,"hits":["meiotic recombination"]},{"slug":"ethics-policy","score":1.0,"hits":["regulatory"]},{"slug":"omics-methods","score":1.0,"hits":["transcriptome"]}],"topic_score":4.0,"preference_score":0.0,"preference_labels":[],"llm_score":72.0,"final_score":80.0,"score_dims":{"novelty":82,"rigor":85,"impact":60,"relevance":55,"translation":35},"recommend_reason":"首次在植物中鉴定减数分裂重组的直接转录调控因子，多组学与遗传挽救实验证据链完整，对理解减数分裂重组的转录调控保守性有参考价值；但研究对象为拟南芥，与人类ART临床距离较远，属机制性基础研究。","keywords":["DREAM复合物","减数分裂重组","转录调控","MER3","拟南芥","MuvB"],"selected":1,"story_id":387,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-top-journals","source_name":"PubMed · CNS/大子刊/四大医学刊（生殖相关）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"sci-adv","journal_tier":"cns-sub","journal_if":11.7,"is_mock":false,"summary_zh":"该研究以拟南芥为模型，鉴定已知DREAM复合物的MuvB核心组分是植物减数分裂重组的关键转录调控因子。敲除TCX5/6与ALY1/2导致重组受损与育性下降；通过减数分裂细胞特异转录组分析与全基因组结合分析，证实包括促交换解旋酶MER3在内的核心重组基因为其直接靶基因，过表达MER3可部分挽救重组缺陷。研究首次在植物中确立减数分裂程序的直接转录调控者，作者提示鉴于DREAM功能异常在动物中亦导致生殖缺陷，该调控机制可能在多细胞真核生物中保守。","summary":"Meiotic chromosome segregation and recombination, essential for sexual reproduction and evolution, require a specialized gene set. Despite its importance, the transcriptional regulators that directly orchestrate meiotic gene expression remain unidentified in plants. We identify the MuvB core components known from the DREAM complex as key transcriptional regulators of meiotic recombination in Arabidopsis. Loss of DREAM components TCX5/6 and ALY1/2 leads to impaired recombination and fertility defects. Meiocyte-specific transcriptome profiling and genome-wide binding analyses reveal that core recombination genes, including the crossover-promoting helicase MER3, are direct targets. Consistently, MER3 overexpression partially rescues recombination defects in DREAM-compromised plants. These findings establish the DREAM complex components as important regulators of the meiotic program in plants. Given that DREAM dysfunction causes reproductive defects in animals, this regulatory role may be conserved across multicellular eukaryotes.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}