{"id":382,"title":"The Nematostella synaptonemal complex mediates divergent and sex-specific meiotic programs","title_zh":"海葵（Nematostella）联会复合体介导分化且具性别差异的减数分裂程序","url":"https://pubmed.ncbi.nlm.nih.gov/42913001","doi":"10.1126/sciadv.aei0758","pmid":"42913001","journal":"Sci Adv","kind":"paper","lang":"en","published_at":"2026-10-23T00:00:00+00:00","fetched_at":"2026-11-08T03:44:12+00:00","authors":["Williams S","Gardner J","Nowotarski SH","Gibson MC"],"primary_topic":"oocyte","topics":[{"slug":"oocyte","score":4.0,"hits":["meiotic"]}],"topic_score":4.0,"preference_score":0.0,"preference_labels":[],"llm_score":60.0,"final_score":68.0,"score_dims":{"novelty":85,"rigor":78,"impact":50,"relevance":42,"translation":22},"recommend_reason":"在非两侧对称动物中首次系统敲除联会复合体核心基因，揭示减数分裂机制的性别二态性与演化分化，对理解减数分裂基本机制有概念性价值；但物种远离哺乳动物，对 ART 与临床的直接可用性有限，属基础生物学外围阅读。","keywords":["联会复合体","减数分裂","性别二态性","sycp1/syce2/sycp3","演化发育生物学","海葵模型"],"selected":1,"story_id":334,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-top-journals","source_name":"PubMed · CNS/大子刊/四大医学刊（生殖相关）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"sci-adv","journal_tier":"cns-sub","journal_if":11.7,"is_mock":false,"summary_zh":"该研究以非两侧对称动物模型海葵 Nematostella vectensis 为对象，证实其同源染色体以经典拉链式方式联会，并表达至少 8 种脊椎动物联会复合体（SC）蛋白的直系同源物（10 种中）。作者对核心 SC 组分 sycp1、syce2、sycp3 进行基因敲除，意外发现表型出现分化并呈性别二态性。结果挑战了“蛋白序列或超微结构保守即意味着机制同源”的假设，提示 SC 功能在演化中存在显著多样化。原文未涉及人类或临床样本。","summary":"Throughout eukaryotes, the synaptonemal complex (SC) is a supramolecular structure essential for meiotic chromosome dynamics and sexual reproduction. While metazoan SC proteins display substantial sequence divergence, the lack of functional analyses beyond bilaterian models has obscured a mechanistic understanding of SC evolution. Here, we report that the sea anemone Nematostella vectensis exhibits synapsis of homologous chromosomes in a classic zipper-like manner and expresses at least eight orthologs of 10 known vertebrate SC proteins. Unexpectedly, mutagenesis of the core SC components sycp1, syce2, and sycp3 resulted in divergent and sexually dimorphic phenotypes, indicating the functional diversification of these conserved factors. Combined, these findings challenge the assumption that the conservation of protein sequence or ultrastructure implies mechanistic homology.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}