{"id":374,"title":"The maternal-fetal interface is an early hematopoietic niche enriched in distinct erythro-myeloid progenitors","title_zh":"小鼠母胎界面被鉴定为富含独特红系-髓系祖细胞的早期造血龛","url":"https://pubmed.ncbi.nlm.nih.gov/42934291","doi":"10.1038/s41590-026-02683-4","pmid":"42934291","journal":"Nat Immunol","kind":"paper","lang":"en","published_at":"2026-10-26T00:00:00+00:00","fetched_at":"2026-11-08T03:44:12+00:00","authors":["Jain R","Tikoo S","Márquez-Burgoa C","Gerhofer SA","Martinez B","Barresi M","Symmank D","Ghannadan M","Öhler B","Höbler AL","E Silva RF","Baumjohann D","Feil S","Feil R","Knapp S","Starkl P","Ellmeier W","Jung S","Pollheimer J","Fraser ST","Weninger W"],"primary_topic":"endometrium","topics":[{"slug":"endometrium","score":5.0,"hits":["maternal-fetal interface","placental"]},{"slug":"repro-immunology","score":1.0,"hits":["macrophage"]}],"topic_score":5.0,"preference_score":0.0,"preference_labels":[],"llm_score":80.0,"final_score":88.0,"score_dims":{"novelty":92,"rigor":85,"impact":82,"relevance":72,"translation":58},"recommend_reason":"该研究拓展了哺乳动物胚胎造血位点图谱，提出母胎界面作为独立造血龛，并有人胎盘绒毛的保守性证据，对早期妊娠与生殖免疫研究有启发；但对ART实验室的直接转化价值目前有限。","keywords":["母胎界面","胚胎造血","红系-髓系祖细胞","胎盘绒毛","谱系追踪","巨噬细胞"],"selected":1,"story_id":320,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-top-journals","source_name":"PubMed · CNS/大子刊/四大医学刊（生殖相关）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nat-immunol","journal_tier":"cns-sub","journal_if":27.7,"is_mock":false,"summary_zh":"该研究在小鼠中发现一个此前未被认识的造血位点——母胎界面MIXER组织，其与卵黄囊同期发育并具活跃造血活性。MIXER富含造血前体，包括经典CSF1R+红系-髓系祖细胞及独特的胚胎CD4+CSF1R-红系-髓系祖细胞（eEMPROR）；谱系追踪显示eEMPROR主要贡献胎儿发育期血管周围巨噬细胞亚群。人早期胎盘绒毛在HSC出现前也含CD4+有核红细胞，提示母胎界面造血功能保守。","summary":"Embryonic hematopoiesis is thought to occur exclusively in the extraembryonic yolk sac before hematopoietic stem cells (HSCs) arise in the aorta-gonad-mesonephros region. Here we identify a previously unrecognized hematopoietic site at the maternal-fetal interface in mice, termed MIXER (Maternally Interfaced eXtraEmbRyonic) tissue, which develops contemporaneously with the yolk sac and exhibits robust hematopoietic activity. MIXER contains abundant hematopoietic precursors, including classical CSF1R+ erythro-myeloid progenitors and a unique embryonic CD4+CSF1R- Erythro-Myeloid PRogenitOR (eEMPROR) population. Lineage-tracing experiments demonstrate that eEMPROR cells contribute to select macrophage subpopulations during fetal development, primarily in the perivascular space. Notably, early human placental villi, before HSC emergence, also harbor CD4+ nucleated erythrocytes, indicating a conserved hematopoietic role for the maternal-fetal interface. These findings establish MIXER as an anatomically distinct niche for embryonic hematopoiesis and expand the developmental map of blood cell emergence in mammals.","interpretation_basis":null,"fulltext_status":"ok","interpretation":null,"fulltext":{"available":true,"status":"ok","reason":"已取得 Europe PMC OA 全文","pmcid":"PMC13710174","license":"CC BY 4.0","chars":29998,"source":"Europe PMC","fetched_at":"2026-11-08T04:17:13+00:00"}}