{"id":362,"title":"Primate embryoids: an in vitro model leading from a totipotency-like phase to early organogenesis","title_zh":"灵长类胚胎样模型：从类全能性阶段走向早期器官发生的体外模型","url":"https://pubmed.ncbi.nlm.nih.gov/42957669","doi":"10.1038/s41392-026-03003-w","pmid":"42957669","journal":"Signal Transduct Target Ther","kind":"paper","lang":"en","published_at":"2026-10-30T00:00:00+00:00","fetched_at":"2026-11-08T03:44:12+00:00","authors":["Tara A","Kues WA"],"primary_topic":"early-embryo","topics":[{"slug":"early-embryo","score":3.0,"hits":["totipotency"]}],"topic_score":3.0,"preference_score":0.0,"preference_labels":[],"llm_score":70.0,"final_score":76.0,"score_dims":{"novelty":72,"rigor":40,"impact":70,"relevance":88,"translation":55},"recommend_reason":"灵长类胚胎样模型是着床前后发育建模的前沿方向，与早期胚胎发育主题高度相关，值得浏览并追溯其引用的原始研究；但本文无摘要、体裁偏评论，缺少可评价的实验细节，严谨性与转化价值暂难判断。","keywords":["灵长类","胚胎样模型","类全能性","早期器官发生","体外胚胎模型","着床前后发育"],"selected":1,"story_id":264,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-top-journals","source_name":"PubMed · CNS/大子刊/四大医学刊（生殖相关）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"sttt","journal_tier":"general-top","journal_if":40.8,"is_mock":false,"summary_zh":"该文为 Signal Transduct Target Ther 刊出的评论/观点类文章（无摘要），主题是灵长类胚胎样（embryoid）体外模型，讨论如何用这类模型重现从类全能性（totipotency-like）状态到早期器官发生的过程。原文未提供摘要，具体实验体系、样本量、验证手段与关键结论均不可见，因此只能判断其议题方向：以非人灵长类为对象构建胚胎样结构，可部分弥补人类胚胎研究的材料与伦理限制，为着床前后发育事件的体外建模提供可能路径。具体数据与结论需查阅原文核实。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}