{"id":358,"title":"Embryonic origin of cancer in newborn twins","title_zh":"新生儿单卵双胎中肿瘤的胚胎起源：经胎盘宫内传播的全基因组系统发育重建","url":"https://pubmed.ncbi.nlm.nih.gov/42966778","doi":"10.1038/s41467-026-78178-5","pmid":"42966778","journal":"Nat Commun","kind":"paper","lang":"en","published_at":"2026-10-06T00:00:00+00:00","fetched_at":"2026-11-08T03:44:12+00:00","authors":["Walkowiak B","Baskind S","Dave M","Balasubramanian P","Anderson N","Kennedy J","Oliver TRW","Verma R","Depani S","Hannam S","Watson T","Rampling D","Straathof K","Palm L","Hutchinson JC","Lee-Six H","Slater O","Behjati S"],"primary_topic":"early-embryo","topics":[{"slug":"endometrium","score":2.0,"hits":["placenta","placental"]}],"topic_score":2.0,"preference_score":0.0,"preference_labels":[],"llm_score":78.0,"final_score":86.0,"score_dims":{"novelty":88,"rigor":85,"impact":75,"relevance":62,"translation":45},"recommend_reason":"以单卵双胎共患癌为天然实验，用全基因组系统发育重建宫内传播与双胎形成早期事件，方法可推广且对双胎形成经典模型提出挑战，对胚胎发育与胎盘谱系研究有启发；但非直接 ART 临床操作内容，转化价值有限。","keywords":["单卵双胎","经胎盘肿瘤传播","全基因组测序","系统发育重建","胚胎谱系","胎盘"],"selected":1,"story_id":421,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-top-journals","source_name":"PubMed · CNS/大子刊/四大医学刊（生殖相关）","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"nat-commun","journal_tier":"cns-sub","journal_if":14.7,"is_mock":false,"summary_zh":"该研究对一对患相同软组织肿瘤的单卵双胎进行多部位肿瘤、正常组织及胎盘样本的全基因组测序，重建肿瘤系统发育树。结果证实肿瘤起源于其中一名胎儿，明确了其分化时间点及经胎盘传播至另一胎的时间，且传播仅发生一次。该方法具有可推广性与可扩展性，同时可解析双胎形成的最早期阶段，发现胚胎谱系对胎盘与两名胎儿的贡献呈意外的不对称性，对经典双胎形成模型提出挑战。","summary":"Studying monozygotic twins who present with identical cancers informs on the developmental origins of childhood tumours. Here, we perform whole genome sequencing on multiple tumour, normal, and placental samples to reconstruct the phylogeny of a soft tissue cancer that spread in utero between monozygotic twins. We demonstrate the origin of the tumour from one twin and time its diversification and transplacental spread to the other twin, showing that the spread occurred only once. This generalisable and scalable approach additionally allows us to dissect the earliest stages of twinning, revealing unexpected asymmetrical contributions of embryonic lineages to the placenta and each twin and challenging the classical model of twinning.","interpretation_basis":null,"fulltext_status":"ok","interpretation":null,"fulltext":{"available":true,"status":"ok","reason":"已取得 Europe PMC OA 全文","pmcid":"PMC13723494","license":"CC BY 4.0","chars":25871,"source":"Europe PMC","fetched_at":"2026-11-08T04:19:45+00:00"}}