{"id":349,"title":"Independent origin of genomic imprinting in placental fish","title_zh":"胎盘鱼中基因组印记的独立起源","url":"https://pubmed.ncbi.nlm.nih.gov/42981403","doi":"10.1126/sciadv.aeh5487","pmid":"42981403","journal":"Sci Adv","kind":"paper","lang":"en","published_at":"2026-11-04T00:00:00+00:00","fetched_at":"2026-11-08T03:44:12+00:00","authors":["Zhang Y","Campbell P","Kingsley A","Reynoso Y","Kang Y","Huang CJ","Werren JH","Reznick D","Wang X"],"primary_topic":"early-embryo","topics":[{"slug":"early-embryo","score":6.0,"hits":["genomic imprinting","imprinted gene","imprinting"]},{"slug":"endometrium","score":5.0,"hits":["placenta","placental"]},{"slug":"repro-genetics","score":1.0,"hits":["dna methylation"]},{"slug":"industry","score":1.0,"hits":["acquisition"]}],"topic_score":6.0,"preference_score":0.0,"preference_labels":[],"llm_score":82.0,"final_score":90.0,"score_dims":{"novelty":96,"rigor":86,"impact":80,"relevance":68,"translation":42},"recommend_reason":"首次在非哺乳脊椎动物（胎盘鱼）展示基因组印记，并给出亲本冲突与DNA甲基化证据，概念新颖；对人类ART直接转化有限，但为印记机制与胎盘进化提供重要比较生物学参照。","keywords":["基因组印记","亲本冲突","胎盘","鱼","DNA甲基化","营养转运"],"selected":1,"story_id":73,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-top-journals","source_name":"PubMed · CNS/大子刊/四大医学刊（生殖相关）","source_tier":1,"mention_count":2,"has_interpretation":false,"journal_key":"sci-adv","journal_tier":"cns-sub","journal_if":11.7,"is_mock":false,"summary_zh":"研究以胎生鱼 Poeciliopsis prolifica 为对象，用两个近交系正反交胎盘转录组鉴定印记，发现84个蛋白编码基因具稳健印记证据，包括哺乳动物印记基因 grb10 的直系同源基因，以及作用相反、印记方向相反的相邻基因 dpp4 与 gcga（涉及糖代谢，可能缓解亲本冲突）。焦点印记基因启动子等位DNA甲基化升高，提示类似哺乳动物的表观机制；并发现营养转运基因网络趋同招募。该研究首次在非哺乳脊椎动物证实基因组印记，支持其解决亲本冲突的假说。","summary":"Genomic imprinting results in biased expression of one parental allele. Such non-Mendelian expression occurs in angiosperms and placental mammals, which share having an active paternal genome during maternal offspring provisioning. It is hypothesized that imprinting modulates conflict between maternal control of resource allocation and paternal control of resource acquisition. If true, then imprinting should evolve in any organism that evolves a placenta. Here, we demonstrate genomic imprinting in a placental poeciliid fish, Poeciliopsis prolifica. Using transcriptomes from reciprocal crosses between two inbred strains, we identified 84 protein-coding genes with robust evidence of imprinting in P. prolifica placenta. These include the teleost ortholog of mammalian imprinted gene, grb10, and a pair of adjacent genes, dpp4 and gcga, with opposing effects on glucose metabolism that are oppositely imprinted in a fashion that potentially resolves parental conflict. Significantly elevated allelic DNA methylation on the promoters of two focal imprinted genes suggests epigenetic mechanisms of imprinting similar to those in mammals. We also discovered the convergent recruitment of a gene network associated with nutrient transport in mammals. To our knowledge, this is the first demonstration of genomic imprinting in a non-mammalian vertebrate and supports the potential role of imprinting in resolving parental conflict.","interpretation_basis":null,"fulltext_status":"not_found","interpretation":null,"fulltext":{"available":false,"status":"not_found","reason":"Europe PMC 无此记录：DOI 10.1126/sciadv.aeh5487","pmcid":null,"license":null,"chars":0,"source":"Europe PMC","fetched_at":"2026-11-08T04:16:31+00:00"}}