{"id":319,"title":"Air pollution and polycystic ovary metabolic syndrome (PMOS) in a heavily industrialized Middle Eastern city: A cross-sectional study","title_zh":"重工业化中东城市长期空气污染暴露与多囊卵巢代谢综合征（PMOS）的横断面关联研究","url":"https://pubmed.ncbi.nlm.nih.gov/42970988","doi":"10.1016/j.chemosphere.2026.145136","pmid":"42970988","journal":"Chemosphere","kind":"paper","lang":"en","published_at":"2026-11-02T00:00:00+00:00","fetched_at":"2026-11-08T03:44:05+00:00","authors":["Karimi B","Kord M","Shokarpour M","Mirhoseini SH"],"primary_topic":"repro-endo","topics":[{"slug":"repro-endo","score":5.0,"hits":["ovulatory","polycystic ovary"]},{"slug":"oocyte","score":4.0,"hits":["ovary"]},{"slug":"repro-tox","score":4.0,"hits":["air pollution"]},{"slug":"contraception-health","score":1.0,"hits":["childbearing"]}],"topic_score":5.0,"preference_score":0.0,"preference_labels":[],"llm_score":64.0,"final_score":64.0,"score_dims":{"novelty":66,"rigor":58,"impact":55,"relevance":66,"translation":48},"recommend_reason":"首次在中东高污染工业区报告长期空气污染暴露与PMOS患病率的统计学关联，为生殖内分泌与环境暴露交叉领域提供假说线索；但横断面设计、单城样本与插值暴露估算限制了因果推断与临床可用性，适合浏览了解方向。","keywords":["空气污染","PM2.5","多囊卵巢代谢综合征","环境暴露","生殖内分泌","横断面研究"],"selected":1,"story_id":185,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-endo-genetics","source_name":"PubMed · 生殖内分泌/遗传/保存","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":null,"journal_tier":"unknown","journal_if":null,"is_mock":false,"summary_zh":"该横断面研究在伊朗重工业城市阿拉克纳入2024年4月至2025年3月妇产科门诊的301名育龄女性（153例PMOS、148例对照），以三座固定监测站的反距离加权插值估算居住地365天长期暴露，采用改良Poisson回归估计患病率比（PR），并以90天、30天暴露窗口、极端值剔除及倾向评分匹配进行稳健性检验。结果显示PMOS组PM2.5、PM10、NO2、SO2暴露均显著更高；每增加1个标准差，调整PR分别为1.22、1.23、1.21、1.15，敏感性分析一致；探索性分析提示关联主要见于月经或排卵功能障碍。作者强调横断面设计无法推断因果，结果仅具假说生成性质，需前瞻性队列验证。","summary":"Globally, polycystic ovary metabolic syndrome (PMOS) affects 5% to 20% of women of childbearing age. Despite the high burden of ambient air pollution in the Middle East, epidemiological evidence linking long-term exposure to PMOS remains limited. This cross-sectional study examined associations between long-term residential exposure to criteria air pollutants and PMOS prevalence in Arak, Iran. We enrolled 301 women (153 PMOS cases, 148 non-PMOS controls) from gynecology clinics (April 2024-March 2025). Long-term (365-day) residential exposures were estimated using inverse distance weighting (IDW) interpolation from three fixed monitoring stations. Modified Poisson regression was prioritized to estimate prevalence ratios (PRs), given the high prevalence of the outcome. Robustness was assessed via alternative exposure windows (90-day, 30-day), extreme value exclusion, and propensity score matching. Women with PMOS had significantly higher exposures to PM2.5 (mean difference: 3.00 μg/m3), PM10 (7.50 μg/m3), NO2 (2.96 ppb), and SO2 (11.35 ppb) (all p ≤ 0.025). Per 1-SD increase, adjusted PRs were: PM2.5 = 1.22 (95% CI: 1.09-1.35; p = 0.001); PM10 = 1.23 (95% CI: 1.09-1.36; p = 0.001); NO2 = 1.21 (95% CI: 1.07-1.33; p = 0.003); and SO2 = 1.15 (95% CI: 1.01-1.28; p = 0.032). All sensitivity analyses supported the robustness of these associations. Exploratory analyses suggested specificity to menstrual/ovulatory dysfunction. This first Middle Eastern study reports statistical associations between long-term PM2.5, PM10, NO2, and SO2 exposure and PMOS prevalence in a high-pollution industrial setting. Because of the cross-sectional design, these findings cannot establish causality and are strictly hypothesis-generating, highlighting the urgent need for prospective cohort studies.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}