{"id":299,"title":"Anti-Müllerian Hormone in Polycystic Ovary Syndrome: Towards a Specific Diagnostic Threshold in the Tunisian Population","title_zh":"多囊卵巢综合征中的抗苗勒管激素：突尼斯人群特异性诊断阈值的探索","url":"https://pubmed.ncbi.nlm.nih.gov/42978814","doi":"10.1016/j.aed.2026.04.017","pmid":"42978814","journal":"AACE Endocrinol Diabetes","kind":"paper","lang":"en","published_at":"2026-05-12T00:00:00+00:00","fetched_at":"2026-11-08T03:44:04+00:00","authors":["Chiboub M","Braham M","Gharbi R","Bennour M","Chakroun N","Hamdoun-Zahmoul M","Feki M","Jemel M","Kammoun I"],"primary_topic":"repro-endo","topics":[{"slug":"repro-endo","score":10.0,"hits":["amh","anti-müllerian","pcos","polycystic ovary"]},{"slug":"oocyte","score":6.0,"hits":["follicles","ovarian","ovary"]},{"slug":"art-clinical","score":1.0,"hits":["infertility"]},{"slug":"repro-tox","score":1.0,"hits":["body mass index"]}],"topic_score":10.0,"preference_score":0.0,"preference_labels":[],"llm_score":70.0,"final_score":70.0,"score_dims":{"novelty":62,"rigor":58,"impact":60,"relevance":90,"translation":75},"recommend_reason":"为PCOS诊断中AMH界值的人群特异性问题提供了具体数据（3.41 ng/mL，AUC 0.977），对生殖内分泌门诊减少超声依赖有实用参考；但样本仅62例、单中心单族群，界值外推性有限，宜作为方法学参考而非直接采纳。","keywords":["抗苗勒管激素","多囊卵巢综合征","诊断阈值","窦卵泡计数","高雄激素血症","人群特异性"],"selected":1,"story_id":479,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-endo-genetics","source_name":"PubMed · 生殖内分泌/遗传/保存","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":null,"journal_tier":"unknown","journal_if":null,"is_mock":false,"summary_zh":"该研究为单中心病例对照研究，纳入按鹿特丹标准诊断的PCOS女性31例及年龄、BMI匹配的对照31例，检测血清抗苗勒管激素（AMH）与睾酮并行超声评估。PCOS组AMH中位数6.92 ng/mL显著高于对照1.90 ng/mL（P<0.001）；以3.41 ng/mL为界值区分PCOS的AUC达0.977，敏感度97%、特异度90%。AMH与窦卵泡数（r=0.846）、卵巢体积（r=0.769）及睾酮（r=0.654）正相关，表型A者AMH最高。作者据此提出突尼斯高雄激素成年女性PCOS诊断的AMH界值，但样本量小、单中心，需外部验证。","summary":"OBJECTIVE: Polycystic ovary syndrome (PCOS) is the leading cause of infertility in women of reproductive age. Its diagnosis can be challenging due to the heterogeneity of presentation, the lack of a single definitive test, and the need to rule out other conditions. The diagnostic criteria are difficult to apply consistently across different individuals and ethnic groups. The study aimed to define a threshold of anti-Müllerian hormone (AMH), which would be predictive of PCOS in the Tunisian population. METHODS: A case-control study was conducted, including 31 women diagnosed with PCOS according to the Rotterdam criteria, and 31 age- and body mass index-matched women without PCOS. All participants underwent medical evaluations, including gynecologic history, physical examination, ovarian ultrasound, and measurements of serum AMH and testosterone concentrations. RESULTS: Serum AMH concentrations were noticeably higher in women with than those without PCOS [median (25th-75th percentile), 6.92 (4.60-10.0) ng/mL versus 1.90 (1.33-2.85) ng/mL; P < 0.001]. A serum AMH concentration of 3.41 ng/mL differentiated women with PCOS from control women with excellent accuracy (median area under the curve, 0.977; sensitivity, 97%; and specificity, 90%). AMH levels were positively correlated with the number of antral follicles (Spearman's r = 0.846; P < 0.001), ovarian volume (Spearman's r = 0.769; P < 0.001), and testosterone levels (Spearman's r = 0.654; P < 0.001). PCOS phenotype A was associated with the highest AMH levels. CONCLUSION: The study suggests that serum AMH is relevant for the diagnosis of PCOS. Based on the findings, we propose a serum AMH cutoff value of 3.41 ng/mL for the diagnosis of PCOS in Tunisian hyperandrogenic adult women.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}