{"id":23,"title":"Editorial: Early embryonic development: zygotic genome activation and epigenome reprogramming","title_zh":"社论：早期胚胎发育中的合子基因组激活与表观基因组重编程","url":"https://pubmed.ncbi.nlm.nih.gov/42964399","doi":"10.3389/fcell.2026.2003264","pmid":"42964399","journal":"Front Cell Dev Biol","kind":"paper","lang":"en","published_at":"2026-10-16T00:00:00+00:00","fetched_at":"2026-11-08T03:43:49+00:00","authors":["Asami M","Liu B","Xia W"],"primary_topic":"early-embryo","topics":[{"slug":"early-embryo","score":6.0,"hits":["early embryonic development","zygotic genome activation"]}],"topic_score":6.0,"preference_score":10.0,"preference_labels":["卵母细胞-胚胎转换 / 母源-合子转换"],"llm_score":58.0,"final_score":68.0,"score_dims":{"novelty":45,"rigor":30,"impact":60,"relevance":92,"translation":40},"recommend_reason":"主题高度契合母源-合子转换与早期胚胎多组学方向，可作为进入该专题的门户；但社论本身无摘要、无原始数据，新颖性与严谨性有限，仅建议浏览并顺藤检索其组织的专题论文。","keywords":["合子基因组激活","表观基因组重编程","母源-合子转换","早期胚胎发育","染色质重塑"],"selected":1,"story_id":397,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-embryo-omics","source_name":"PubMed · 胚胎/卵母细胞组学","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":"front-cdb","journal_tier":"standard","journal_if":4.6,"is_mock":false,"summary_zh":"本条为 Front Cell Dev Biol 发表的社论（Editorial），主题聚焦早期胚胎发育中的合子基因组激活（ZGA）与表观基因组重编程，作者 Asami M、Liu B、Xia W。PubMed 记录未提供摘要或正文内容，因此无法获知该社论的具体论点、引用文献范围及其组织的专题文章构成。结合标题与期刊定位推断，其内容应围绕母源-合子转换（MZT）过程中转录沉默解除、染色质开放性建立、组蛋白修饰与 DNA 甲基化重塑等机制展开，并可能汇总该专题下多篇原始研究。由于缺少实质内容，本条目更适合作为专题入口用于检索追踪，而非直接获取新数据或新结论。","summary":"","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}