{"id":228,"title":"Decidua-accumulated effector-like memory CD8+ T cells orchestrate localized antimicrobial defense without compromising fetal tolerance","title_zh":"蜕膜富集的效应样记忆CD8+T细胞经CX3CL1-CX3CR1轴实现局部抗感染防御而不破坏胎儿免疫耐受","url":"https://pubmed.ncbi.nlm.nih.gov/42986696","doi":"10.1172/jci202874","pmid":"42986696","journal":"J Clin Invest","kind":"paper","lang":"en","published_at":"2026-11-05T00:00:00+00:00","fetched_at":"2026-11-08T03:44:00+00:00","authors":["Liu L","Huang X","Yin T","Hu X","Yu H","Zhu G","Xu C","Chen J","Du J","Wang H","Wu Q","Zhang W","Wang F","Wu H","Du M"],"primary_topic":"endometrium","topics":[{"slug":"endometrium","score":9.0,"hits":["decidua","decidual","decidualization","maternal-fetal interface","placenta","uterine"]}],"topic_score":9.0,"preference_score":0.0,"preference_labels":[],"llm_score":83.0,"final_score":83.0,"score_dims":{"novelty":86,"rigor":85,"impact":80,"relevance":82,"translation":65},"recommend_reason":"首次在人鼠两物种中定义蜕膜富集的效应样记忆CD8+T细胞亚群，并用趋化因子轴功能实验证明其“抗感染不伤胎儿”的分区免疫机制，为早期妊娠感染性流产与母胎免疫耐受研究提供新靶点。","keywords":["蜕膜化","记忆CD8+T细胞","CX3CL1-CX3CR1轴","母胎界面免疫","胎儿耐受","妊娠感染"],"selected":1,"story_id":50,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-uterus-pregnancy","source_name":"PubMed · 内膜/植入/早孕","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":null,"journal_tier":"unknown","journal_if":null,"is_mock":false,"summary_zh":"该研究探索母胎界面如何兼顾免疫防御与胎儿耐受。作者在人与小鼠中鉴定出一群蜕膜富集的效应样记忆CD8+T细胞（人CD45RA+、小鼠CX3CR1+），蜕膜为CX3CL1优势的趋化因子微环境；敲除Cx3cr1或子宫Cx3cl1可削弱其蜕膜募集与定位。人鼠该群细胞转录与功能特征保守，细胞毒性增强但炎性细胞因子产生受限。CX3CL1介导的CD8+T细胞聚集可改善孕期李斯特菌感染的局部控制并减少感染相关流产；而胎儿抗原特异性CD8+T细胞聚集与吸收则不依赖子宫CX3CL1。结论：母胎界面是主动的免疫守门人，通过保守的CX3CL1-CX3CR1轴区室化抗微生物适应性免疫。","summary":"Deciphering immune privilege at the maternal-fetal interface is essential for understanding how reproductive success and host defense are simultaneously maintained. Decidualization, occurring within the specialized stromal tissue encapsulating the fetus and placenta, shapes local immune adaptation required for healthy pregnancy. Here, we identify a decidua-enriched effector-like memory CD8+ T cell subset marked by CD45RA in humans and CX3CR1 in mice. These cells preferentially accumulate in the decidua, which harbors a CX3CL1-dominant chemokine niche, and disruption of Cx3cr1 or uterine Cx3cl1 impaired their decidual recruitment and tissue localization. Human CD45RA+ and murine CX3CR1+ decidual memory CD8+ T cells shared conserved transcriptional and functional features, including enhanced cytotoxic potential and limited inflammatory cytokine production. Functionally, CX3CL1-mediated CD8+ T cell accumulation improved local control of prenatal Listeria monocytogenes infection and reduced infection-associated fetal loss. In contrast, fetal antigen-specific CD8+ T cell accumulation and fetal resorption occurred independently of uterine CX3CL1. Together, our findings define the maternal-fetal interface as an active immunological gatekeeper, that compartmentalizing CD8+ T cell-mediated antimicrobial adaptive immunity through the conserved CX3CL1-CX3CR1 axis, supporting pathogen-specific defense while preserving fetal tolerance.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}