{"id":206,"title":"The selection and fate of mitochondria in the female germline of the whirligig beetle, Gyrinus natator. A deviation from the Drosophila model","title_zh":"鼓甲（Gyrinus natator）雌性生殖系中线粒体的选择与命运：不同于果蝇模型的新机制","url":"https://pubmed.ncbi.nlm.nih.gov/42966302","doi":"10.1016/j.tice.2026.104100","pmid":"42966302","journal":"Tissue Cell","kind":"paper","lang":"en","published_at":"2026-10-27T00:00:00+00:00","fetched_at":"2026-11-08T03:43:57+00:00","authors":["Jaglarz MK"],"primary_topic":"repro-aging","topics":[{"slug":"repro-aging","score":5.0,"hits":["mitochondria","mitochondrial"]},{"slug":"ivg-stem","score":4.0,"hits":["germline"]},{"slug":"animal-models","score":3.2,"hits":["drosophila"]},{"slug":"oocyte","score":3.0,"hits":["oocyte","oocytes","ovarian"]}],"topic_score":5.0,"preference_score":0.0,"preference_labels":[],"llm_score":62.0,"final_score":62.0,"score_dims":{"novelty":78,"rigor":66,"impact":42,"relevance":45,"translation":28},"recommend_reason":"在非模式昆虫中发现 Bb 样结构早于卵母细胞决定形成，并揭示内质网—线粒体网络—线粒体自噬参与线粒体筛选与生殖质传递，对理解母源线粒体遗传与质量控制有比较生物学价值；但属基础动物学，与人类 ART 的直接转化距离较远。","keywords":["Balbiani body","线粒体质量控制","线粒体自噬","生殖质","卵巢 cyst","比较生殖生物学"],"selected":1,"story_id":309,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-gametes","source_name":"PubMed · 配子与性腺","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":null,"journal_tier":"unknown","journal_if":null,"is_mock":false,"summary_zh":"该研究以鼓甲 Gyrinus natator 的卵巢 cyst 为对象，用荧光与超微结构分析追踪生殖系细胞中线粒体的分布与命运。与果蝇不同，鼓甲卵母细胞不含 Balbiani body（Bb），但在卵母细胞决定之前，生殖系细胞中已形成由线粒体和特定细胞器组成的 Bb 样结构；其行为受内质网池调控，参与功能异常线粒体的筛选与清除，依赖线粒体网络与线粒体自噬；部分被选中的线粒体与 sponge body 结合，被转运至卵母细胞后部生殖质。作者据此提出线粒体质量控制与传递模型。","summary":"The Balbiani body (Bb), a characteristic assembly of mitochondria and diverse organelles, occurs in oocytes of model species, including Drosophila melanogaster. Several functions that are critical for the proper development of oocytes and embryos have been attributed to Bb. Surprisingly, Bb has not been reported in oocytes of numerous insects, suggesting the potential absence of this structure in certain species. Here, we explore the distribution and fate of mitochondria during ovarian cyst development in the whirligig beetle, Gyrinus natator. In this species, oocytes do not contain Bb. However, a distinct assemblage of mitochondria and specific organelles, corresponding to Bb, forms in the germline cells of the ovarian cyst prior to the determination of the oocyte, indicating a novel mechanism of the Bb functioning. Fluorescent and ultrastructural analyses of the Gyrinus germline cells at different developmental stages also revealed that the behavior and fate of mitochondria are modulated by interactions with cisternae of the endoplasmic reticulum. We demonstrate that Gyrinus Bbs are involved in the selection and elimination of dysfunctional mitochondria and that these processes rely on mitochondrial networks and mitophagy. Furthermore, we found that a subset of mitochondria is associated with characteristic cellular structures termed sponge bodies. This association appears to facilitate the transport of the selected mitochondria to the germ plasm that forms within the posterior cytoplasm of the oocyte. Based on these results, a model for mitochondrial quality control and transfer within the ovarian cyst of G. natator is proposed.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}