{"id":174,"title":"Protective effect of Livergol® on reproductive complications in a rat model of experimental cholestasis","title_zh":"水飞蓟素制剂 Livergol® 对实验性胆汁淤积大鼠生殖并发症的保护作用","url":"https://pubmed.ncbi.nlm.nih.gov/42979507","doi":"10.30466/vrf.2026.2078938.5005","pmid":"42979507","journal":"Vet Res Forum","kind":"paper","lang":"en","published_at":"2026-08-15T00:00:00+00:00","fetched_at":"2026-11-08T03:43:57+00:00","authors":["Shariatpanahi SS","Mohammadi R","Shalizar-Jalali A","Najafi G"],"primary_topic":"male","topics":[{"slug":"male","score":4.0,"hits":["epididymal","sperm","spermatogenesis","testicular"]},{"slug":"repro-tox","score":1.0,"hits":["reproductive toxicity"]}],"topic_score":4.0,"preference_score":0.0,"preference_labels":[],"llm_score":58.0,"final_score":58.0,"score_dims":{"novelty":45,"rigor":50,"impact":35,"relevance":55,"translation":40},"recommend_reason":"属于生殖毒理动物实验，验证了已知抗氧化药物对胆汁淤积性睾丸损伤的保护作用，但每组仅 5 只、机制证据间接，与辅助生殖临床决策距离较远，可作为背景知识浏览。","keywords":["胆汁淤积","水飞蓟素","睾丸损伤","精子参数","生殖毒理","大鼠模型"],"selected":0,"story_id":445,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-gametes","source_name":"PubMed · 配子与性腺","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":null,"journal_tier":"unknown","journal_if":null,"is_mock":false,"summary_zh":"研究以 20 只成年雄性 Wistar 大鼠随机分为对照、假手术、胆管结扎（BDL）致胆汁淤积及胆汁淤积+Livergol®（水飞蓟素制剂，300 mg/kg 灌胃 4 周）四组，每组 5 只。结果显示 BDL 使睾丸 Johnsen 评分下降、Cosentino 标准升高，附睾精子计数、活力与活动率显著降低；Livergol® 处理后上述指标均显著改善。作者认为其保护作用可能与活性成分水飞蓟素的抗氧化特性有关，提示其对胆汁淤积所致生殖毒性具有潜在防护价值。样本量小、缺乏氧化应激直接指标与剂量梯度，结论尚属初步。","summary":"Cholestasis, a multi-faceted liver complication arising from an imbalance in bile production and secretion, can lead to damage in extra-hepatic organs, including the reproductive system. This study aimed to investigate the therapeutic potential of Livergol®, a silymarin-based drug, in the reproductive complications induced by experimental cholestasis in mature male rats. Twenty adults male Wistar rats were randomly divided into four groups (n = 5), including group 1 (control) remained untreated, group 2 (sham) underwent laparotomy and bile duct manipulation without ligation, group 3 (cholestasis) underwent bile duct ligation (BDL) to induce experimental cholestasis, and group 4 (cholestasis + Livergol®) received oral Livergol® (300 mg kg-1) for 4 weeks post-BDL. After the study period, testicular histopathology was evaluated using Johnsen's score and the Cosentino criterion. Epididymal sperm parameters, including count, viability, and motility, were also assessed. The BDL-induced cholestasis caused significant testicular damage, evidenced by a decreased Johnsen's score and an increased Cosentino criterion. It also led to a significant reduction in sperm count, viability, and motility. Treatment with Livergol® significantly ameliorated these effects, leading to a higher Johnsen's score, a lower Cosentino criterion, and marked improvements in all evaluated sperm parameters compared to the untreated cholestatic group. Oral administration of Livergol® effectively attenuates testicular damage and improves spermatogenesis and sperm quality in rats with experimental cholestasis. These findings suggest Livergol® as a promising protective agent against cholestasis-induced reproductive toxicity, likely due to the anti-oxidant properties of its active component, silymarin.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}