{"id":172,"title":"Advances in Understanding the Mechanisms of Oxidative Stress in Infertile Obese Men","title_zh":"肥胖相关男性不育中氧化应激机制研究进展","url":"https://pubmed.ncbi.nlm.nih.gov/42980021","doi":"10.31083/fbl48702","pmid":"42980021","journal":"Front Biosci (Landmark Ed)","kind":"paper","lang":"en","published_at":"2026-10-15T00:00:00+00:00","fetched_at":"2026-11-08T03:43:57+00:00","authors":["Xie J","Zhang Y","Sun P","Ma H"],"primary_topic":"art-clinical","topics":[{"slug":"art-clinical","score":4.0,"hits":["infertile","infertility"]},{"slug":"male","score":2.0,"hits":["male infertility","sperm"]}],"topic_score":4.0,"preference_score":0.0,"preference_labels":[],"llm_score":72.0,"final_score":72.0,"score_dims":{"novelty":60,"rigor":62,"impact":72,"relevance":85,"translation":70},"recommend_reason":"选题贴合男性不育与精子质量的临床核心问题，系统梳理氧化应激这一可干预靶点，对实验室抗氧化策略与临床评估思路有参考价值；但属叙述性综述、缺乏原始数据与定量整合，创新性有限。","keywords":["肥胖","男性不育","氧化应激","精子质量","炎症与凋亡"],"selected":1,"story_id":401,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-gametes","source_name":"PubMed · 配子与性腺","source_tier":1,"mention_count":1,"has_interpretation":false,"journal_key":null,"journal_tier":"standard","journal_if":null,"is_mock":false,"summary_zh":"本文为综述，聚焦肥胖相关男性不育中氧化应激的作用机制。作者整合近期研究，指出氧化应激可影响生殖激素水平、精子质量与生殖器官功能，并可能通过诱导炎症反应、促进细胞凋亡等途径加重不育。文章认为，尽管该领域已有一定进展，但具体生物学机制与干预策略仍需深入探究，综述旨在为开发新的治疗途径提供基础。原文未提供纳入文献数量、检索策略等细节，也未报告原始数据。","summary":"Obesity-related male infertility has emerged as a significant global health concern, impacting both reproductive ability and overall well-being in men. A critical factor in the pathogenesis of infertility among obese men is oxidative stress, which not only affects reproductive hormone levels, sperm quality, and the function of reproductive organs but also potentially worsens infertility through mechanisms such as inducing inflammatory responses and promoting cell apoptosis. Although there has been some progress in understanding how oxidative stress contributes to obesity-related male infertility, further investigations into its specific biological mechanisms and potential intervention strategies are needed. The aim of this review was to synthesize recent research advances on oxidative stress in the context of obesity-related male infertility, thereby providing a foundation for the development of new therapeutic approaches.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}