{"id":170,"title":"Oxidative-antioxidant imbalance in female infertility: evaluation of serum biomarkers and their diagnostic potential","title_zh":"女性不孕症中的氧化-抗氧化失衡：血清生物标志物评估及其诊断潜力","url":"https://pubmed.ncbi.nlm.nih.gov/42980065","doi":"10.1080/17520363.2026.2753292","pmid":"42980065","journal":"Biomark Med","kind":"paper","lang":"en","published_at":"2026-11-04T00:00:00+00:00","fetched_at":"2026-11-08T03:43:57+00:00","authors":["Bahri F","Norouzmahani ME","Moshrefi M","Habibi S","Rad I","Asadikaram G","Faramarz S","Abdollahdokht D","Habibzadeh V","Orandi S","Nematollahi MH"],"primary_topic":"art-clinical","topics":[{"slug":"art-clinical","score":5.0,"hits":["infertile","infertility"]},{"slug":"repro-endo","score":4.0,"hits":["diminished ovarian reserve","dor","pcos","polycystic ovary"]},{"slug":"oocyte","score":2.0,"hits":["ovarian reserve","ovary"]},{"slug":"endometrium","score":1.0,"hits":["endometriosis"]}],"topic_score":5.0,"preference_score":0.0,"preference_labels":[],"llm_score":68.0,"final_score":68.0,"score_dims":{"novelty":55,"rigor":70,"impact":60,"relevance":78,"translation":65},"recommend_reason":"该研究为女性不孕症的氧化应激评估提供了较系统的血清标志物比较，TAC的诊断区分能力对临床无创筛查有参考价值；但病例对照设计、单次血清检测及缺乏外部验证限制了结论强度，适合浏览。","keywords":["氧化应激","总抗氧化能力","女性不孕","生物标志物","铁代谢","ROC曲线"],"selected":1,"story_id":91,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-gametes","source_name":"PubMed · 配子与性腺","source_tier":1,"mention_count":2,"has_interpretation":false,"journal_key":null,"journal_tier":"unknown","journal_if":null,"is_mock":false,"summary_zh":"该病例对照研究纳入300名女性，其中250例不孕症患者按病因分为卵巢储备减退、多囊卵巢综合征、输卵管因素、子宫内膜异位症及不明原因不孕，另设50名生育力正常对照，检测血清总抗氧化能力（TAC）、超氧化物歧化酶（SOD）活性、铁、铜及生殖激素，并进行相关性与ROC分析。结果显示，不孕组TAC显著降低、铁显著升高，SOD与铜亦升高；TAC对区分各不孕亚组与对照的诊断表现最佳，且铁与TAC呈显著负相关。结论认为氧化-抗氧化系统失衡与女性不孕相关，TAC可能作为无创生物标志物，但需进一步验证。","summary":"AIMS: Oxidative stress (OS) is implicated in the pathogenesis of female reproductive disorders and may contribute to infertility. This study evaluated serum OS-related biomarkers and their diagnostic potential in women with different causes of infertility. MATERIALS AND METHODS: In this case-control study, 300 women were enrolled, including 250 infertile women with diminished ovarian reserve (DOR), polycystic ovary syndrome (PCOS), tubal factor infertility (TF), endometriosis (EM), or unexplained infertility (UI), and 50 fertile controls. Serum total antioxidant capacity (TAC), superoxide dismutase (SOD) activity, iron (Fe), copper (Cu), and reproductive hormone concentrations were measured. Correlation and receiver operating characteristic (ROC) curve analyses were performed. RESULTS: Compared with fertile controls, infertile women had significantly lower serum TAC levels (p < 0.001) and higher Fe concentrations (p < 0.001). SOD activity and Cu concentrations were also significantly higher among infertile women (p < 0.05). ROC curve analysis showed the best diagnostic performance of TAC to distinguish all subgroups of infertility from fertile controls. Serum Fe levels were negatively and significantly correlated with the levels of TAC. CONCLUSION: An imbalance between oxidative and antioxidative systems is associated with female infertility. TAC demonstrated the highest discriminative ability and may represent a useful noninvasive biomarker of infertility-associated OS.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}