{"id":129,"title":"ART utilization outcomes and trends for single and coupled male intended parents at a large fertility centre","title_zh":"单人与伴侣男性意向父母在大型生殖中心的辅助生殖利用结局与趋势","url":"https://pubmed.ncbi.nlm.nih.gov/42966174","doi":"10.1016/j.rbmo.2026.106016","pmid":"42966174","journal":"Reprod Biomed Online","kind":"paper","lang":"en","published_at":"2026-10-06T00:00:00+00:00","fetched_at":"2026-11-08T03:43:53+00:00","authors":["Patel K","Morse B","Sakkas D","Penzias A","Resetkova N"],"primary_topic":"art-clinical","topics":[{"slug":"art-clinical","score":7.0,"hits":["assisted reproductive","embryo transfer","gestational carrier","infertility","live birth","live birth rate","oocyte donation"]},{"slug":"oocyte","score":1.0,"hits":["oocyte"]},{"slug":"pgt","score":1.0,"hits":["preimplantation genetic"]},{"slug":"embryology-lab","score":1.0,"hits":["warming"]},{"slug":"early-pregnancy","score":1.0,"hits":["pregnancy outcomes"]},{"slug":"contraception-health","score":1.0,"hits":["birth rate"]}],"topic_score":7.0,"preference_score":5.0,"preference_labels":["可转化到 ART 实验室的发现"],"llm_score":74.0,"final_score":79.0,"score_dims":{"novelty":68,"rigor":72,"impact":66,"relevance":96,"translation":72},"recommend_reason":"基于较大单中心队列补充了男性意向父母辅助生殖结局证据，对临床咨询、供卵方案选择及PGT-A预期管理有参考价值；但为回顾性描述性研究，统计效能和推广性有限。","keywords":["男性意向父母","供卵","妊娠代孕","活产率","PGT-A","辅助生殖技术"],"selected":1,"story_id":422,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-art","source_name":"PubMed · 辅助生殖临床","source_tier":1,"mention_count":3,"has_interpretation":false,"journal_key":"rbmo","journal_tier":"standard","journal_if":3.7,"is_mock":false,"summary_zh":"该回顾性研究分析美国一家学术型不孕中心2014—2023年395名单身或伴侣男性意向父母（SCMIP）的辅助生殖资料，其中149人接受供卵和/或妊娠代孕胚胎移植。新鲜供卵周期平均获胚8.0枚，冻卵周期3.3枚；每次胚胎移植活产率新鲜与冻卵相似（55.4% vs 52.8%），PGT-A未见明显影响。累计移植后87%获得活产，初诊至移植平均1.6年。提示SCMIP辅助生殖使用增加且结局良好，但过程耗时。","summary":"RESEARCH QUESTION: What are the updated outcomes and trends regarding assisted reproductive technology (ART) for single and coupled male intended parents (SCMIP) undergoing family building? DESIGN: A retrospective analysis was performed at a single, academically affiliated infertility centre in the USA from 2014 to 2023. SCMIP that underwent an initial consultation, or initiated treatment with oocyte donation and/or embryo transfer via a gestational carrier were included. Demographic data, oocyte donation cycle outcomes, embryo transfer data, and pregnancy outcomes were obtained from the cohort of SCMIP. RESULTS: In total, 395 SCMIP had an initial consultation during the study period and 149 (37.7%) (23 single males, 126 male couples) underwent treatment. The mean age at initial consultation was 38.1 years; data over time show a trend towards initiating care at a younger age. One hundred and thirty-three fresh oocyte retrieval cycles, 51 frozen oocyte warming cycles, and 222 embryo transfers were performed. The mean number of embryos obtained per cycle was 8.0 (SD 5.7) in fresh oocyte donation cycles versus 3.3 (SD 2.5) in frozen oocyte donation cycles. The live birth rate per embryo transfer was similar when comparing fresh oocyte donation with frozen oocyte donation (55.4% versus 52.8%, respectively; P = 0.86). The use of preimplantation genetic testing for aneuploidy did not impact treatment success. Overall, after all cumulative embryo transfers via a gestational carrier in the study period, 87% of SCMIP achieved a live birth, with an average latency of 1.6 years between initial consultation and embryo transfer. CONCLUSION: This large data set of male patients illustrates that, despite the significant time and costs associated with the process, SCMIP are increasingly accessing ART to achieve fatherhood with good success.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}