{"id":128,"title":"Public knowledge and attitudes towards non-conventional gestation in the UK: results from a cross-sectional online survey experiment","title_zh":"英国公众对非常规妊娠（代孕、子宫移植与人工胎盘）的认知与态度：一项横断面在线调查实验","url":"https://pubmed.ncbi.nlm.nih.gov/42966175","doi":"10.1016/j.rbmo.2026.105983","pmid":"42966175","journal":"Reprod Biomed Online","kind":"paper","lang":"en","published_at":"2026-09-24T00:00:00+00:00","fetched_at":"2026-11-08T03:43:53+00:00","authors":["Park-Morton L","Relja R","Adkins V"],"primary_topic":"ethics-policy","topics":[{"slug":"endometrium","score":2.0,"hits":["placenta","uterus"]},{"slug":"art-clinical","score":1.0,"hits":["surrogacy"]}],"topic_score":2.0,"preference_score":0.0,"preference_labels":[],"llm_score":62.0,"final_score":62.0,"score_dims":{"novelty":66,"rigor":72,"impact":52,"relevance":58,"translation":40},"recommend_reason":"样本量较大、随机分组设计规范的公众态度研究，为子宫移植、人工胎盘等前沿技术的伦理与政策讨论提供一手民意数据；但属于社会调查范畴，与ART实验室和临床决策的直接关联有限，方法学上为横断面、complete-case分析，因果推断受限。","keywords":["非常规妊娠","代孕","子宫移植","人工胎盘","公众态度","调查实验"],"selected":1,"story_id":432,"llm_provider":"deepseek","llm_model":"deepseek-flash","llm_effort":"low","source_key":"pubmed-art","source_name":"PubMed · 辅助生殖临床","source_tier":1,"mention_count":2,"has_interpretation":false,"journal_key":"rbmo","journal_tier":"standard","journal_if":3.7,"is_mock":false,"summary_zh":"该研究采用配额抽样的横断面在线调查实验，在英国招募1646名成人，随机分入代孕（n=548）、子宫移植（UTx，n=549）或人工胎盘（n=549）三组，并在组内比较传统代孕与妊娠代孕、活体与 deceased 供体子宫移植。结果显示，对代孕、UTx和人工胎盘持积极态度的比例分别为85.9%、82.0%和64.8%；提供具体变体信息后支持率有所下降，但仍偏正面，各变体间支持度差异不显著。74.3%–82.7%的受访者自评对该领域知识了解甚少；主观知识水平较高者态度更积极，尤其对人工胎盘（β=0.38）；年龄较小者对UTx及人工胎盘更支持，宗教信仰降低对代孕的支持，政治取向则与UTx支持度正相关。作者结论认为，公众对非常规妊娠的支持受信息详略、主观知识及社会人口学因素影响，且在不同技术类型和变体间存在差异。","summary":"RESEARCH QUESTION: What does the British public know and think about three forms of non-conventional gestation (NCG) - surrogacy, uterus transplantation (UTx) and artificial placentas - and their variants: traditional surrogacy, gestational surrogacy and UTx from living (LUTx) versus deceased (DUTx) donors? DESIGN: A quota-sampled cross-sectional online survey experiment in the UK recruited 1646 adults (51% female) via a research panel. Respondents were randomly assigned to surrogacy (n = 548), UTx (n = 549) or artificial placenta (n = 549) conditions. Within-subject ratings assessed traditional versus gestational surrogacy and LUTx versus DUTx. Subjective knowledge and attitudes were measured before sociodemographic variables. Complete-case data were analysed using analysis of variance, correlations and linear regressions. RESULTS: The percentage of respondents with positive attitudes varied across surrogacy (85.9%; n = 471/548), UTx (82.0%; n = 450/549) and artificial placentas (64.8%; n = 356/549). Variant-specific information reduced support for surrogacy and UTx, although attitudes remained favourable. Differences in support between surrogacy/UTx, traditional/gestational surrogacy and LUTx/DUTx were not significant. Most participants (74.3-82.7%) reported low knowledge of NCG. Higher subjective knowledge predicted more positive attitudes towards UTx (β = 0.11), LUTx (β = 0.13) and artificial placentas (β = 0.38). Age negatively predicted attitudes towards UTx (β = -0.20), LUTx (β = -0.14) and artificial placentas (β = -0.22), indicating that younger respondents were more supportive of these newer NCG, while older age predicted greater support only for traditional surrogacy (β = 0.11). Religion predicted lower support for surrogacy (β = -0.15), traditional surrogacy (β = -0.10) and gestational surrogacy (β = -0.10). Political orientation predicted higher support for UTx (β = 0.15), LUTx (β = 0.10) and DUTx (β = 0.09). Other demographics had minimal effects. CONCLUSIONS: Public support for NCG is shaped by the level of detail provided as well as subjective knowledge and sociodemographic factors, although associations vary across NCG forms and variants. Further research should examine information sources and other influences on attitudes.","interpretation_basis":null,"fulltext_status":null,"interpretation":null,"fulltext":{"available":false,"status":null,"reason":"尚未抓取全文（未入选、分数未达阈值，或还没跑 fulltext 步骤）","pmcid":null,"license":null,"chars":0,"source":null,"fetched_at":null}}